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TAPAS-1, a novel microdomain within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid.
Baillie GS, Huston E, Scotland G, Hodgkin M, Gall I, Peden AH, MacKenzie C, Houslay ES, Currie R, Pettitt TR, Walmsley AR, Wakelam MJ, Warwicker J, Houslay MD. Baillie GS, et al. Among authors: houslay md, houslay es. J Biol Chem. 2002 Aug 2;277(31):28298-309. doi: 10.1074/jbc.M108353200. Epub 2002 May 6. J Biol Chem. 2002. PMID: 11994273 Free article.
The human cyclic AMP-specific phosphodiesterase PDE-46 (HSPDE4A4B) expressed in transfected COS7 cells occurs as both particulate and cytosolic species that exhibit distinct kinetics of inhibition by the antidepressant rolipram.
Huston E, Pooley L, Julien P, Scotland G, McPhee I, Sullivan M, Bolger G, Houslay MD. Huston E, et al. Among authors: houslay md. J Biol Chem. 1996 Dec 6;271(49):31334-44. doi: 10.1074/jbc.271.49.31334. J Biol Chem. 1996. PMID: 8940140 Free article.
Association with the SRC family tyrosyl kinase LYN triggers a conformational change in the catalytic region of human cAMP-specific phosphodiesterase HSPDE4A4B. Consequences for rolipram inhibition.
McPhee I, Yarwood SJ, Scotland G, Huston E, Beard MB, Ross AH, Houslay ES, Houslay MD. McPhee I, et al. Among authors: houslay md, houslay es. J Biol Chem. 1999 Apr 23;274(17):11796-810. doi: 10.1074/jbc.274.17.11796. J Biol Chem. 1999. PMID: 10206997 Free article.
413 results