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Dihydroxy-7-methoxy-1,4-benzoxazin-3-one (DIMBOA) and 2,4-dihydroxy-1,4-benzoxazin-3-one (DIBOA), two naturally occurring benzoxazinones contained in sprouts of Gramineae are potent aneugens in human-derived liver cells (HepG2).
Buchmann CA, Nersesyan A, Kopp B, Schauberger D, Darroudi F, Grummt T, Krupitza G, Kundi M, Schulte-Hermann R, Knasmueller S. Buchmann CA, et al. Among authors: knasmueller s. Cancer Lett. 2007 Feb 8;246(1-2):290-9. doi: 10.1016/j.canlet.2006.03.013. Epub 2006 Apr 27. Cancer Lett. 2007. PMID: 16644106
Impact of spinach consumption on DNA stability in peripheral lymphocytes and on biochemical blood parameters: results of a human intervention trial.
Moser B, Szekeres T, Bieglmayer C, Wagner KH, Mišík M, Kundi M, Zakerska O, Nersesyan A, Kager N, Zahrl J, Hoelzl C, Ehrlich V, Knasmueller S. Moser B, et al. Among authors: knasmueller s. Eur J Nutr. 2011 Oct;50(7):587-94. doi: 10.1007/s00394-011-0167-6. Epub 2011 Mar 9. Eur J Nutr. 2011. PMID: 21384253 Clinical Trial.
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