Schmeiser HH - Search Results

1

Carcinogenic aristolochic acids upon activation by DT-diaphorase form adducts found in DNA of patients with Chinese herbs nephropathy.

Stiborová M, Frei E, Sopko B, Wiessler M, Schmeiser HH. Stiborová M, et al. Among authors: schmeiser hh. Carcinogenesis. 2002 Apr;23(4):617-25. doi: 10.1093/carcin/23.4.617. Carcinogenesis. 2002. PMID: 11960915

2

Human cytosolic enzymes involved in the metabolic activation of carcinogenic aristolochic acid: evidence for reductive activation by human NAD(P)H:quinone oxidoreductase.

Stiborová M, Frei E, Sopko B, Sopková K, Marková V, Lanková M, Kumstýrová T, Wiessler M, Schmeiser HH. Stiborová M, et al. Among authors: schmeiser hh. Carcinogenesis. 2003 Oct;24(10):1695-703. doi: 10.1093/carcin/bgg119. Epub 2003 Jul 17. Carcinogenesis. 2003. PMID: 12869422

3

Identification of a genotoxic mechanism for 2-nitroanisole carcinogenicity and of its carcinogenic potential for humans.

Stiborová M, Miksanová M, Smrcek S, Bieler CA, Breuer A, Klokow KA, Schmeiser HH, Frei E. Stiborová M, et al. Among authors: schmeiser hh. Carcinogenesis. 2004 May;25(5):833-40. doi: 10.1093/carcin/bgh061. Epub 2004 Jan 16. Carcinogenesis. 2004. PMID: 14729594

4

Human hepatic and renal microsomes, cytochromes P450 1A1/2, NADPH:cytochrome P450 reductase and prostaglandin H synthase mediate the formation of aristolochic acid-DNA adducts found in patients with urothelial cancer.

Stiborová M, Frei E, Hodek P, Wiessler M, Schmeiser HH. Stiborová M, et al. Among authors: schmeiser hh. Int J Cancer. 2005 Jan 10;113(2):189-97. doi: 10.1002/ijc.20564. Int J Cancer. 2005. PMID: 15386410

5

The binding of aristolochic acid I to the active site of human cytochromes P450 1A1 and 1A2 explains their potential to reductively activate this human carcinogen.

Stiborová M, Sopko B, Hodek P, Frei E, Schmeiser HH, Hudecek J. Stiborová M, et al. Among authors: schmeiser hh. Cancer Lett. 2005 Nov 18;229(2):193-204. doi: 10.1016/j.canlet.2005.06.038. Epub 2005 Aug 24. Cancer Lett. 2005. PMID: 16125300

6

Metabolic activation of carcinogenic aristolochic acid, a risk factor for Balkan endemic nephropathy.

Stiborová M, Frei E, Arlt VM, Schmeiser HH. Stiborová M, et al. Among authors: schmeiser hh. Mutat Res. 2008 Jan-Feb;658(1-2):55-67. doi: 10.1016/j.mrrev.2007.07.003. Epub 2007 Aug 6. Mutat Res. 2008. PMID: 17851120 Free article. Review.

7

Human cytochromes P450 1A1 and 1A2 participate in detoxication of carcinogenic aristolochic acid.

Sistkova J, Hudecek J, Hodek P, Frei E, Schmeiser HH, Stiborova M. Sistkova J, et al. Among authors: schmeiser hh. Neuro Endocrinol Lett. 2008 Oct;29(5):733-7. Neuro Endocrinol Lett. 2008. PMID: 18987598

8

The role of biotransformation enzymes in the development of renal injury and urothelial cancer caused by aristolochic acid: urgent questions and difficult answers.

Stiborova M, Frei E, Arlt VM, Schmeiser HH. Stiborova M, et al. Among authors: schmeiser hh. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2009 Mar;153(1):5-11. doi: 10.5507/bp.2009.001. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2009. PMID: 19365519 Free article. Review.

9

Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model.

Levová K, Moserová M, Kotrbová V, Sulc M, Henderson CJ, Wolf CR, Phillips DH, Frei E, Schmeiser HH, Mares J, Arlt VM, Stiborová M. Levová K, et al. Among authors: schmeiser hh. Toxicol Sci. 2011 May;121(1):43-56. doi: 10.1093/toxsci/kfr050. Epub 2011 Feb 28. Toxicol Sci. 2011. PMID: 21362632 Free article.

10

The human carcinogen aristolochic acid i is activated to form DNA adducts by human NAD(P)H:quinone oxidoreductase without the contribution of acetyltransferases or sulfotransferases.

Stiborová M, Mareš J, Frei E, Arlt VM, Martínek V, Schmeiser HH. Stiborová M, et al. Among authors: schmeiser hh. Environ Mol Mutagen. 2011 Jul;52(6):448-59. doi: 10.1002/em.20642. Epub 2011 Mar 2. Environ Mol Mutagen. 2011. PMID: 21370283

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