Smith BR - Search Results

1

SB-242235, a selective inhibitor of p38 mitogen-activated protein kinase. I: preclinical pharmacokinetics.

Ward KW, Proksch JW, Salyers KL, Azzarano LM, Morgan JA, Roethke TJ, McSurdy-Freed JE, Levy MA, Smith BR. Ward KW, et al. Among authors: smith br. Xenobiotica. 2002 Mar;32(3):221-33. doi: 10.1080/00498250110100720. Xenobiotica. 2002. PMID: 11958561 Clinical Trial.

2

Pharmacokinetics of SB-247083, a potent and selective endothelin(A) receptor antagonist, in the rat, dog, and monkey.

Ward KW, Azzarano LM, Morgan JA, Gould MJ, Perng CY, Souder PR, Lundberg D, Smith BR. Ward KW, et al. Among authors: smith br. Biopharm Drug Dispos. 2002 Nov;23(8):339-49. doi: 10.1002/bdd.331. Biopharm Drug Dispos. 2002. PMID: 12415574

3

Development of an in vivo preclinical screen model to estimate absorption and first-pass hepatic extraction of xenobiotics. II. Use of ketoconazole to identify P-glycoprotein/CYP3A-limited bioavailability in the monkey.

Ward KW, Stelman GJ, Morgan JA, Zeigler KS, Azzarano LM, Kehler JR, McSurdy-Freed JE, Proksch JW, Smith BR. Ward KW, et al. Among authors: smith br. Drug Metab Dispos. 2004 Feb;32(2):172-7. doi: 10.1124/dmd.32.2.172. Drug Metab Dispos. 2004. PMID: 14744938

4

A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. I. Clearance.

Ward KW, Smith BR. Ward KW, et al. Among authors: smith br. Drug Metab Dispos. 2004 Jun;32(6):603-11. doi: 10.1124/dmd.32.6.603. Drug Metab Dispos. 2004. PMID: 15155551

5

A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. II. Volume of distribution and mean residence time.

Ward KW, Smith BR. Ward KW, et al. Among authors: smith br. Drug Metab Dispos. 2004 Jun;32(6):612-9. doi: 10.1124/dmd.32.6.612. Drug Metab Dispos. 2004. PMID: 15155552

6

Preclinical pharmacokinetics and interspecies scaling of a novel vitronectin receptor antagonist.

Ward KW, Azzarano LM, Bondinell WE, Cousins RD, Huffman WF, Jakas DR, Keenan RM, Ku TW, Lundberg D, Miller WH, Mumaw JA, Newlander KA, Pirhalla JL, Roethke TJ, Salyers KL, Souder PR, Stelman GJ, Smith BR. Ward KW, et al. Among authors: smith br. Drug Metab Dispos. 1999 Nov;27(11):1232-41. Drug Metab Dispos. 1999. PMID: 10534306

7

Development of an in vivo preclinical screen model to estimate absorption and bioavailability of xenobiotics.

Ward KW, Proksch JW, Levy MA, Smith BR. Ward KW, et al. Among authors: smith br. Drug Metab Dispos. 2001 Jan;29(1):82-8. Drug Metab Dispos. 2001. PMID: 11124234

8

SB-239063, a potent and selective inhibitor of p38 map kinase: preclinical pharmacokinetics and species-specific reversible isomerization.

Ward KW, Proksch JW, Azzarano LM, Salyers KL, McSurdy-Freed JE, Molnar TM, Levy MA, Smith BR. Ward KW, et al. Among authors: smith br. Pharm Res. 2001 Sep;18(9):1336-44. doi: 10.1023/a:1013002414678. Pharm Res. 2001. PMID: 11683250

9

Preclinical pharmacokinetics of SB-203580, a potent inhibitor of p38 mitogen-activated protein kinase.

Ward KW, Prokscht JW, Azzaranot LM, Mumawa JA, Roethke TJ, Stelman GJ, Walsh MJ, Zeigler KS, McSurdy-Freed JE, Kehlert JR, Chokshi J, Levy MA, Smith BR. Ward KW, et al. Among authors: smith br. Xenobiotica. 2001 Nov;31(11):783-97. doi: 10.1080/00498250110065621. Xenobiotica. 2001. PMID: 11765141

10

SB-242235, a selective inhibitor of p38 mitogen-activated protein kinase. II: in vitro and in vivo metabolism studies and pharmacokinetic extrapolation to man.

Ward KW, Proksch JW, Gorycki PD, Yu CP, Ho MY, Bush BD, Levy MA, Smith BR. Ward KW, et al. Among authors: smith br. Xenobiotica. 2002 Mar;32(3):235-50. doi: 10.1080/00498250110100711. Xenobiotica. 2002. PMID: 11958562

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