Levy MA - Search Results

1

SB-242235, a selective inhibitor of p38 mitogen-activated protein kinase. I: preclinical pharmacokinetics.

Ward KW, Proksch JW, Salyers KL, Azzarano LM, Morgan JA, Roethke TJ, McSurdy-Freed JE, Levy MA, Smith BR. Ward KW, et al. Among authors: levy ma. Xenobiotica. 2002 Mar;32(3):221-33. doi: 10.1080/00498250110100720. Xenobiotica. 2002. PMID: 11958561 Clinical Trial.

2

Development of an in vivo preclinical screen model to estimate absorption and bioavailability of xenobiotics.

Ward KW, Proksch JW, Levy MA, Smith BR. Ward KW, et al. Among authors: levy ma. Drug Metab Dispos. 2001 Jan;29(1):82-8. Drug Metab Dispos. 2001. PMID: 11124234

3

SB-239063, a potent and selective inhibitor of p38 map kinase: preclinical pharmacokinetics and species-specific reversible isomerization.

Ward KW, Proksch JW, Azzarano LM, Salyers KL, McSurdy-Freed JE, Molnar TM, Levy MA, Smith BR. Ward KW, et al. Among authors: levy ma. Pharm Res. 2001 Sep;18(9):1336-44. doi: 10.1023/a:1013002414678. Pharm Res. 2001. PMID: 11683250

4

Preclinical pharmacokinetics of SB-203580, a potent inhibitor of p38 mitogen-activated protein kinase.

Ward KW, Prokscht JW, Azzaranot LM, Mumawa JA, Roethke TJ, Stelman GJ, Walsh MJ, Zeigler KS, McSurdy-Freed JE, Kehlert JR, Chokshi J, Levy MA, Smith BR. Ward KW, et al. Among authors: levy ma. Xenobiotica. 2001 Nov;31(11):783-97. doi: 10.1080/00498250110065621. Xenobiotica. 2001. PMID: 11765141

5

SB-242235, a selective inhibitor of p38 mitogen-activated protein kinase. II: in vitro and in vivo metabolism studies and pharmacokinetic extrapolation to man.

Ward KW, Proksch JW, Gorycki PD, Yu CP, Ho MY, Bush BD, Levy MA, Smith BR. Ward KW, et al. Among authors: levy ma. Xenobiotica. 2002 Mar;32(3):235-50. doi: 10.1080/00498250110100711. Xenobiotica. 2002. PMID: 11958562

6

Evaluation of the use of accelerated infusions for the determination of pharmacokinetic linearity.

Ward KW, Griffiths R, Levy MA, Smith BR. Ward KW, et al. Among authors: levy ma. J Pharmacol Exp Ther. 2000 May;293(2):468-79. J Pharmacol Exp Ther. 2000. PMID: 10773017

7

Enhancement of in vitro and in vivo microdialysis recovery of SB-265123 using Intralipid and Encapsin as perfusates.

Ward KW, Medina SJ, Portelli ST, Mahar Doan KM, Spengler MD, Ben MM, Lundberg D, Levy MA, Chen EP. Ward KW, et al. Among authors: levy ma. Biopharm Drug Dispos. 2003 Jan;24(1):17-25. doi: 10.1002/bdd.332. Biopharm Drug Dispos. 2003. PMID: 12516075

8

Metabolism and disposition of eltrombopag, an oral, nonpeptide thrombopoietin receptor agonist, in healthy human subjects.

Deng Y, Madatian A, Wire MB, Bowen C, Park JW, Williams D, Peng B, Schubert E, Gorycki F, Levy M, Gorycki PD. Deng Y, et al. Drug Metab Dispos. 2011 Sep;39(9):1734-46. doi: 10.1124/dmd.111.040170. Epub 2011 Jun 6. Drug Metab Dispos. 2011. PMID: 21646437 Clinical Trial.

9

Design of potent and selective human cathepsin K inhibitors that span the active site.

Thompson SK, Halbert SM, Bossard MJ, Tomaszek TA, Levy MA, Zhao B, Smith WW, Abdel-Meguid SS, Janson CA, D'Alessio KJ, McQueney MS, Amegadzie BY, Hanning CR, DesJarlais RL, Briand J, Sarkar SK, Huddleston MJ, Ijames CF, Carr SA, Garnes KT, Shu A, Heys JR, Bradbeer J, Zembryki D, Lee-Rykaczewski L, James IE, Lark MW, Drake FH, Gowen M, Gleason JG, Veber DF. Thompson SK, et al. Among authors: levy ma. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14249-54. doi: 10.1073/pnas.94.26.14249. Proc Natl Acad Sci U S A. 1997. PMID: 9405598 Free PMC article.

10

Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality.

Lee D, Long SA, Adams JL, Chan G, Vaidya KS, Francis TA, Kikly K, Winkler JD, Sung CM, Debouck C, Richardson S, Levy MA, DeWolf WE Jr, Keller PM, Tomaszek T, Head MS, Ryan MD, Haltiwanger RC, Liang PH, Janson CA, McDevitt PJ, Johanson K, Concha NO, Chan W, Abdel-Meguid SS, Badger AM, Lark MW, Nadeau DP, Suva LJ, Gowen M, Nuttall ME. Lee D, et al. Among authors: levy ma. J Biol Chem. 2000 May 26;275(21):16007-14. doi: 10.1074/jbc.275.21.16007. J Biol Chem. 2000. PMID: 10821855 Free article.

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