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Clinical phase II study and pharmacological evaluation of rubitecan in non-pretreated patients with metastatic colorectal cancer-significant effect of food intake on the bioavailability of the oral camptothecin analogue.
Schöffski P, Herr A, Vermorken JB, Van den Brande J, Beijnen JH, Rosing H, Volk J, Ganser A, Adank S, Botma HJ, Wanders J. Schöffski P, et al. Among authors: botma hj. Eur J Cancer. 2002 Apr;38(6):807-13. doi: 10.1016/s0959-8049(02)00022-9. Eur J Cancer. 2002. PMID: 11937315 Clinical Trial.