Yamazaki H - Search Results

1

Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli.

Yamazaki H, Nakamura M, Komatsu T, Ohyama K, Hatanaka N, Asahi S, Shimada N, Guengerich FP, Shimada T, Nakajima M, Yokoi T. Yamazaki H, et al. Protein Expr Purif. 2002 Apr;24(3):329-37. doi: 10.1006/prep.2001.1578. Protein Expr Purif. 2002. PMID: 11922748

2

Formation of a novel quinone epoxide metabolite of troglitazone with cytotoxicity to HepG2 cells.

Yamamoto Y, Yamazaki H, Ikeda T, Watanabe T, Iwabuchi H, Nakajima M, Yokoi T. Yamamoto Y, et al. Among authors: yamazaki h. Drug Metab Dispos. 2002 Feb;30(2):155-60. doi: 10.1124/dmd.30.2.155. Drug Metab Dispos. 2002. PMID: 11792684

3

Evaluation of approach to predict the contribution of multiple cytochrome P450s in drug metabolism using relative activity factor: effects of the differences in expression levels of NADPH-cytochrome P450 reductase and cytochrome b(5) in the expression system and the differences in the marker activities.

Nakajima M, Tane K, Nakamura S, Shimada N, Yamazaki H, Yokoi T. Nakajima M, et al. Among authors: yamazaki h. J Pharm Sci. 2002 Apr;91(4):952-63. doi: 10.1002/jps.10091. J Pharm Sci. 2002. PMID: 11948533

4

Identification of catalase in human livers as a factor that enhances phenytoin dihydroxy metabolite formation by human liver microsomes.

Komatsu T, Yamazaki H, Nakajima M, Yokoi T. Komatsu T, et al. Among authors: yamazaki h. Biochem Pharmacol. 2002 Jun 15;63(12):2081-90. doi: 10.1016/s0006-2952(02)01024-9. Biochem Pharmacol. 2002. PMID: 12110367

5

Genotoxic activation of benzophenone and its two metabolites by human cytochrome P450s in SOS/umu assay.

Takemoto K, Yamazaki H, Nakajima M, Yokoi T. Takemoto K, et al. Among authors: yamazaki h. Mutat Res. 2002 Aug 26;519(1-2):199-204. doi: 10.1016/s1383-5718(02)00141-9. Mutat Res. 2002. PMID: 12160905

6

Decreased coumarin 7-hydroxylase activities and CYP2A6 expression levels in humans caused by genetic polymorphism in CYP2A6 promoter region (CYP2A6*9).

Kiyotani K, Yamazaki H, Fujieda M, Iwano S, Matsumura K, Satarug S, Ujjin P, Shimada T, Guengerich FP, Parkinson A, Honda G, Nakagawa K, Ishizaki T, Kamataki T. Kiyotani K, et al. Among authors: yamazaki h. Pharmacogenetics. 2003 Nov;13(11):689-95. doi: 10.1097/00008571-200311000-00005. Pharmacogenetics. 2003. PMID: 14583682

7

Effects of cytochrome b(5) on drug oxidation activities of human cytochrome P450 (CYP) 3As: similarity of CYP3A5 with CYP3A4 but not CYP3A7.

Yamaori S, Yamazaki H, Suzuki A, Yamada A, Tani H, Kamidate T, Fujita Ki, Kamataki T. Yamaori S, et al. Among authors: yamazaki h. Biochem Pharmacol. 2003 Dec 15;66(12):2333-40. doi: 10.1016/j.bcp.2003.08.004. Biochem Pharmacol. 2003. PMID: 14637191

8

Establishment of ten strains of genetically engineered Salmonella typhimurium TA1538 each co-expressing a form of human cytochrome P450 with NADPH-cytochrome P450 reductase sensitive to various promutagens.

Yamazaki Y, Fujita K, Nakayama K, Suzuki A, Nakamura K, Yamazaki H, Kamataki T. Yamazaki Y, et al. Among authors: yamazaki h. Mutat Res. 2004 Aug 8;562(1-2):151-62. doi: 10.1016/j.mrgentox.2004.06.003. Mutat Res. 2004. PMID: 15279838

9

CYP3A5 Contributes significantly to CYP3A-mediated drug oxidations in liver microsomes from Japanese subjects.

Yamaori S, Yamazaki H, Iwano S, Kiyotani K, Matsumura K, Honda G, Nakagawa K, Ishizaki T, Kamataki T. Yamaori S, et al. Among authors: yamazaki h. Drug Metab Pharmacokinet. 2004 Apr;19(2):120-9. doi: 10.2133/dmpk.19.120. Drug Metab Pharmacokinet. 2004. PMID: 15499178 Free article.

10

Activities of cytochrome p450 enzymes in liver and kidney microsomes from systemic carnitine deficiency mice with a gene mutation of carnitine/organic cation transporter.

Yamazaki H, Iketaki H, Shibata A, Nakajima M, Yokoi T. Yamazaki H, et al. Drug Metab Pharmacokinet. 2002;17(1):47-53. doi: 10.2133/dmpk.17.47. Drug Metab Pharmacokinet. 2002. PMID: 15618652 Free article.

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