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Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli.
Yamazaki H, Nakamura M, Komatsu T, Ohyama K, Hatanaka N, Asahi S, Shimada N, Guengerich FP, Shimada T, Nakajima M, Yokoi T. Yamazaki H, et al. Among authors: komatsu t. Protein Expr Purif. 2002 Apr;24(3):329-37. doi: 10.1006/prep.2001.1578. Protein Expr Purif. 2002. PMID: 11922748
Involvement of microsomal cytochrome P450 and cytosolic thymidine phosphorylase in 5-fluorouracil formation from tegafur in human liver.
Komatsu T, Yamazaki H, Shimada N, Nagayama S, Kawaguchi Y, Nakajima M, Yokoi T. Komatsu T, et al. Clin Cancer Res. 2001 Mar;7(3):675-81. Clin Cancer Res. 2001. PMID: 11297264
Recently, we have reported that tegafur, an anticancer agent, is biotransformed into active drug 5-fluorouracil (5-FU) by cytochromes P450 1A2, 2A6, and 2C8 in human liver microsomes (T. Komatsu et al., Drug Metab. Dispos, 28: 1457-1463, 2000). Because the conversio …
Recently, we have reported that tegafur, an anticancer agent, is biotransformed into active drug 5-fluorouracil (5-FU) by cytochromes P450 1 …
Single-Molecule Oxidoreductase Activity Analysis for Activity-Based Diagnosis Based on Proteoform Alterations.
Minoda M, Hatakeyama J, Nagano N, Mizuno T, Iwasaka T, Shiga S, Takahashi K, Hiraide H, Sakamoto S, Kagami Y, Kashiro A, Honda K, Sugiura Y, Mishima K, Mishima MK, Kusuhara H, Urano Y, Komatsu T. Minoda M, et al. Among authors: komatsu t. J Am Chem Soc. 2025 Jan 6. doi: 10.1021/jacs.4c07624. Online ahead of print. J Am Chem Soc. 2025. PMID: 39762186
1,751 results