Haining RL - Search Results

1

Polymorphic variants (CYP2C9*3 and CYP2C9*5) and the F114L active site mutation of CYP2C9: effect on atypical kinetic metabolism profiles.

Tracy TS, Hutzler JM, Haining RL, Rettie AE, Hummel MA, Dickmann LJ. Tracy TS, et al. Among authors: haining rl. Drug Metab Dispos. 2002 Apr;30(4):385-90. doi: 10.1124/dmd.30.4.385. Drug Metab Dispos. 2002. PMID: 11901091

2

Differential activation of CYP2C9 variants by dapsone.

Hummel MA, Dickmann LJ, Rettie AE, Haining RL, Tracy TS. Hummel MA, et al. Among authors: haining rl. Biochem Pharmacol. 2004 May 15;67(10):1831-41. doi: 10.1016/j.bcp.2004.01.017. Biochem Pharmacol. 2004. PMID: 15130760

3

(+)-N-3-Benzyl-nirvanol and (-)-N-3-benzyl-phenobarbital: new potent and selective in vitro inhibitors of CYP2C19.

Suzuki H, Kneller MB, Haining RL, Trager WF, Rettie AE. Suzuki H, et al. Among authors: haining rl. Drug Metab Dispos. 2002 Mar;30(3):235-9. doi: 10.1124/dmd.30.3.235. Drug Metab Dispos. 2002. PMID: 11854139

4

Expression, purification, biochemical characterization, and comparative function of human cytochrome P450 2D6.1, 2D6.2, 2D6.10, and 2D6.17 allelic isoforms.

Yu A, Kneller BM, Rettie AE, Haining RL. Yu A, et al. Among authors: haining rl. J Pharmacol Exp Ther. 2002 Dec;303(3):1291-300. doi: 10.1124/jpet.102.039891. J Pharmacol Exp Ther. 2002. PMID: 12438554

5

CYP2C-catalyzed delta9-tetrahydrocannabinol metabolism: kinetics, pharmacogenetics and interaction with phenytoin.

Bland TM, Haining RL, Tracy TS, Callery PS. Bland TM, et al. Among authors: haining rl. Biochem Pharmacol. 2005 Oct 1;70(7):1096-103. doi: 10.1016/j.bcp.2005.07.007. Biochem Pharmacol. 2005. PMID: 16112652

6

Flunitrazepam metabolism by cytochrome P450S 2C19 and 3A4.

Kilicarslan T, Haining RL, Rettie AE, Busto U, Tyndale RF, Sellers EM. Kilicarslan T, et al. Among authors: haining rl. Drug Metab Dispos. 2001 Apr;29(4 Pt 1):460-5. Drug Metab Dispos. 2001. PMID: 11259331

7

The human intestinal cytochrome P450 "pie".

Paine MF, Hart HL, Ludington SS, Haining RL, Rettie AE, Zeldin DC. Paine MF, et al. Among authors: haining rl. Drug Metab Dispos. 2006 May;34(5):880-6. doi: 10.1124/dmd.105.008672. Epub 2006 Feb 7. Drug Metab Dispos. 2006. PMID: 16467132 Free PMC article.

8

Enzymatic determinants of the substrate specificity of CYP2C9: role of B'-C loop residues in providing the pi-stacking anchor site for warfarin binding.

Haining RL, Jones JP, Henne KR, Fisher MB, Koop DR, Trager WF, Rettie AE. Haining RL, et al. Biochemistry. 1999 Mar 16;38(11):3285-92. doi: 10.1021/bi982161+. Biochemistry. 1999. PMID: 10079071

9

Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen.

Dong H, Haining RL, Thummel KE, Rettie AE, Nelson SD. Dong H, et al. Among authors: haining rl. Drug Metab Dispos. 2000 Dec;28(12):1397-400. Drug Metab Dispos. 2000. PMID: 11095574

10

N-oxygenation of clozapine by flavin-containing monooxygenase.

Tugnait M, Hawes EM, McKay G, Rettie AE, Haining RL, Midha KK. Tugnait M, et al. Among authors: haining rl. Drug Metab Dispos. 1997 Apr;25(4):524-7. Drug Metab Dispos. 1997. PMID: 9107553

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