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Discovery and Early Clinical Development of Isobutyl 1-[8-Methoxy-5-(1-oxo-3H-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxylate (LEO 39652), a Novel "Dual-Soft" PDE4 Inhibitor for Topical Treatment of Atopic Dermatitis.
Larsen J, Lambert M, Pettersson H, Vifian T, Larsen M, Ollerstam A, Hegardt P, Eskilsson C, Laursen S, Soehoel A, Skak-Nielsen T, Hansen LM, Knudsen NØ, Eirefelt S, Sørensen MD, Stilou TG, Nielsen SF. Larsen J, et al. Among authors: hegardt p. J Med Chem. 2020 Dec 10;63(23):14502-14521. doi: 10.1021/acs.jmedchem.0c00797. Epub 2020 Oct 15. J Med Chem. 2020. PMID: 33054196
Discovery and early clinical development of 2-{6-[2-(3,5-dichloro-4-pyridyl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a soft-drug inhibitor of phosphodiesterase 4 for topical treatment of atopic dermatitis.
Felding J, Sørensen MD, Poulsen TD, Larsen J, Andersson C, Refer P, Engell K, Ladefoged LG, Thormann T, Vinggaard AM, Hegardt P, Søhoel A, Nielsen SF. Felding J, et al. Among authors: hegardt p. J Med Chem. 2014 Jul 24;57(14):5893-903. doi: 10.1021/jm500378a. Epub 2014 Jul 1. J Med Chem. 2014. PMID: 24984230 Review.
[Kala-azar -- an unusual import disease].
Carlsson MG, Hegardt P. Carlsson MG, et al. Among authors: hegardt p. Lakartidningen. 1977 Aug 17;74(33):2763-4. Lakartidningen. 1977. PMID: 895294 Swedish. No abstract available.