Holthuysen AE - Search Results

1

Local overexpression of adeno-viral IL-4 protects cartilage from metallo proteinase-induced destruction during immune complex-mediated arthritis by preventing activation of pro-MMPs.

van Lent PL, Holthuysen AE, Slöetjes A, Lubberts E, van den Berg WB. van Lent PL, et al. Among authors: holthuysen ae. Osteoarthritis Cartilage. 2002 Mar;10(3):234-43. doi: 10.1053/joca.2001.0501. Osteoarthritis Cartilage. 2002. PMID: 11869085 Free article.

2

FcgammaRI up-regulation induced by local adenoviral-mediated interferon-gamma production aggravates chondrocyte death during immune complex-mediated arthritis.

Nabbe KC, van Lent PL, Holthuysen AE, Kolls JK, Verbeek S, van den Berg WB. Nabbe KC, et al. Among authors: holthuysen ae. Am J Pathol. 2003 Aug;163(2):743-52. doi: 10.1016/s0002-9440(10)63701-7. Am J Pathol. 2003. PMID: 12875993 Free PMC article.

3

Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis.

Blom AB, van Lent PL, Holthuysen AE, van der Kraan PM, Roth J, van Rooijen N, van den Berg WB. Blom AB, et al. Among authors: holthuysen ae. Osteoarthritis Cartilage. 2004 Aug;12(8):627-35. doi: 10.1016/j.joca.2004.03.003. Osteoarthritis Cartilage. 2004. PMID: 15262242 Free article.

4

Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation.

Nabbe KC, van Lent PL, Holthuysen AE, Sloëtjes AW, Koch AE, Radstake TR, van den Berg WB. Nabbe KC, et al. Among authors: holthuysen ae. Arthritis Res Ther. 2005;7(2):R392-401. doi: 10.1186/ar1502. Epub 2005 Jan 26. Arthritis Res Ther. 2005. PMID: 15743487 Free PMC article.

5

NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-gamma-stimulated immune complex arthritis.

van Lent PL, Nabbe KC, Blom AB, Sloetjes A, Holthuysen AE, Kolls J, Van De Loo FA, Holland SM, Van Den Berg WB. van Lent PL, et al. Among authors: holthuysen ae. Arthritis Res Ther. 2005;7(4):R885-95. doi: 10.1186/ar1760. Epub 2005 May 20. Arthritis Res Ther. 2005. PMID: 15987491 Free PMC article.

6

Coordinate expression of activating Fc gamma receptors I and III and inhibiting Fc gamma receptor type II in the determination of joint inflammation and cartilage destruction during immune complex-mediated arthritis.

Nabbe KC, Blom AB, Holthuysen AE, Boross P, Roth J, Verbeek S, van Lent PL, van den Berg WB. Nabbe KC, et al. Among authors: holthuysen ae. Arthritis Rheum. 2003 Jan;48(1):255-65. doi: 10.1002/art.10721. Arthritis Rheum. 2003. PMID: 12528127 Free article.

7

Joint inflammation and chondrocyte death become independent of Fcgamma receptor type III by local overexpression of interferon-gamma during immune complex-mediated arthritis.

Nabbe KC, Boross P, Holthuysen AE, Sloëtjes AW, Kolls JK, Verbeek S, van Lent PL, van Den Berg WB. Nabbe KC, et al. Among authors: holthuysen ae. Arthritis Rheum. 2005 Mar;52(3):967-74. doi: 10.1002/art.20874. Arthritis Rheum. 2005. PMID: 15751061 Free article.

8

Active matrix metalloproteinases are present in cartilage during immune complex-mediated arthritis: a pivotal role for stromelysin-1 in cartilage destruction.

van Meurs J, van Lent P, Holthuysen A, Lambrou D, Bayne E, Singer I, van den Berg W. van Meurs J, et al. J Immunol. 1999 Nov 15;163(10):5633-9. J Immunol. 1999. PMID: 10553093

9

Major role for interleukin 1 but not for tumor necrosis factor in early cartilage damage in immune complex arthritis in mice.

Van Lent PL, Van De Loo FA, Holthuysen AE, Van Den Bersselaar LA, Vermeer H, Van Den Berg WB. Van Lent PL, et al. Among authors: holthuysen ae. J Rheumatol. 1995 Dec;22(12):2250-8. J Rheumatol. 1995. PMID: 8835558

10

Monocytes/macrophages rather than PMN are involved in early cartilage degradation in cationic immune complex arthritis in mice.

Van Lent PL, Blom A, Holthuysen AE, Jacobs CW, Van De Putte LB, Van Den Berg WB. Van Lent PL, et al. Among authors: holthuysen ae. J Leukoc Biol. 1997 Mar;61(3):267-78. doi: 10.1002/jlb.61.3.267. J Leukoc Biol. 1997. PMID: 9060449 Free article.

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