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Page 1
Asymmetric synthesis of BB-3497--a potent peptide deformylase inhibitor.
Pratt LM, Beckett RP, Davies SJ, Launchbury SB, Miller A, Spavold ZM, Todd RS, Whittaker M. Pratt LM, et al. Among authors: beckett rp. Bioorg Med Chem Lett. 2001 Oct 8;11(19):2585-8. doi: 10.1016/s0960-894x(01)00509-1. Bioorg Med Chem Lett. 2001. PMID: 11551755
The synthesis of novel matrix metalloproteinase inhibitors employing the Ireland-Claisen rearrangement.
Pratt LM, Beckett RP, Bellamy CL, Corkill DJ, Cossins J, Courtney PF, Davies SJ, Davidson AH, Drummond AH, Helfrich K, Lewis CN, Mangan M, Martin FM, Miller K, Nayee P, Ricketts ML, Thomas W, Todd RS, Whittaker M. Pratt LM, et al. Among authors: beckett rp. Bioorg Med Chem Lett. 1998 Jun 2;8(11):1359-64. doi: 10.1016/s0960-894x(98)00218-2. Bioorg Med Chem Lett. 1998. PMID: 9871766
Structure-activity relationships of the peptide deformylase inhibitor BB-3497: modification of the methylene spacer and the P1' side chain.
Davies SJ, Ayscough AP, Beckett RP, Bragg RA, Clements JM, Doel S, Grew C, Launchbury SB, Perkins GM, Pratt LM, Smith HK, Spavold ZM, Thomas SW, Todd RS, Whittaker M. Davies SJ, et al. Among authors: beckett rp. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2709-13. doi: 10.1016/s0960-894x(03)00532-8. Bioorg Med Chem Lett. 2003. PMID: 12873499
Peptide deformylase inhibitors with activity against respiratory tract pathogens.
East SP, Beckett RP, Brookings DC, Clements JM, Doel S, Keavey K, Pain G, Smith HK, Thomas W, Thompson AJ, Todd RS, Whittaker M. East SP, et al. Among authors: beckett rp. Bioorg Med Chem Lett. 2004 Jan 5;14(1):59-62. doi: 10.1016/j.bmcl.2003.10.013. Bioorg Med Chem Lett. 2004. PMID: 14684298
Antibiotic activity and characterization of BB-3497, a novel peptide deformylase inhibitor.
Clements JM, Beckett RP, Brown A, Catlin G, Lobell M, Palan S, Thomas W, Whittaker M, Wood S, Salama S, Baker PJ, Rodgers HF, Barynin V, Rice DW, Hunter MG. Clements JM, et al. Among authors: beckett rp. Antimicrob Agents Chemother. 2001 Feb;45(2):563-70. doi: 10.1128/AAC.45.2.563-570.2001. Antimicrob Agents Chemother. 2001. PMID: 11158755 Free PMC article.
50 results