Le Bonniec B - Search Results

1

Molecular determinants of the mechanism underlying acceleration of the interaction between antithrombin and factor Xa by heparin pentasaccharide.

Quinsey NS, Whisstock JC, Le Bonniec B, Louvain V, Bottomley SP, Pike RN. Quinsey NS, et al. Among authors: le bonniec b. J Biol Chem. 2002 May 3;277(18):15971-8. doi: 10.1074/jbc.M108131200. Epub 2002 Feb 19. J Biol Chem. 2002. PMID: 11854268 Free article.

2

The elusive role of the potential factor X cation-binding exosite-1 in substrate and inhibitor interactions.

Bianchini EP, Pike RN, Le Bonniec BF. Bianchini EP, et al. J Biol Chem. 2004 Jan 30;279(5):3671-9. doi: 10.1074/jbc.M309691200. Epub 2003 Oct 28. J Biol Chem. 2004. PMID: 14583605 Free article.

3

Determination of the P1', P2' and P3' subsite-specificity of factor Xa.

Ludeman JP, Pike RN, Bromfield KM, Duggan PJ, Cianci J, Le Bonniec B, Whisstock JC, Bottomley SP. Ludeman JP, et al. Among authors: le bonniec b. Int J Biochem Cell Biol. 2003 Feb;35(2):221-5. doi: 10.1016/s1357-2725(02)00128-0. Int J Biochem Cell Biol. 2003. PMID: 12479872

4

Structure of a serpin-enzyme complex probed by cysteine substitutions and fluorescence spectroscopy.

Ludeman JP, Whisstock JC, Hopkins PC, Le Bonniec BF, Bottomley SP. Ludeman JP, et al. Among authors: le bonniec bf. Biophys J. 2001 Jan;80(1):491-7. doi: 10.1016/S0006-3495(01)76031-6. Biophys J. 2001. PMID: 11159419 Free PMC article.

5

Mapping of the catalytic groove preferences of factor Xa reveals an inadequate selectivity for its macromolecule substrates.

Bianchini EP, Louvain VB, Marque PE, Juliano MA, Juliano L, Le Bonniec BF. Bianchini EP, et al. Among authors: le bonniec bf. J Biol Chem. 2002 Jun 7;277(23):20527-34. doi: 10.1074/jbc.M201139200. Epub 2002 Mar 29. J Biol Chem. 2002. PMID: 11925440 Free article.

6

Control of the coagulation system by serpins. Getting by with a little help from glycosaminoglycans.

Pike RN, Buckle AM, le Bonniec BF, Church FC. Pike RN, et al. FEBS J. 2005 Oct;272(19):4842-51. doi: 10.1111/j.1742-4658.2005.04880.x. FEBS J. 2005. PMID: 16176258 Free article. Review.

7

Characterization of the specificity of arginine-specific gingipains from Porphyromonas gingivalis reveals active site differences between different forms of the enzymes.

Ally N, Whisstock JC, Sieprawska-Lupa M, Potempa J, Le Bonniec BF, Travis J, Pike RN. Ally N, et al. Biochemistry. 2003 Oct 14;42(40):11693-700. doi: 10.1021/bi0349726. Biochemistry. 2003. PMID: 14529279

8

Cleaved antitrypsin polymers at atomic resolution.

Dunstone MA, Dai W, Whisstock JC, Rossjohn J, Pike RN, Feil SC, Le Bonniec BF, Parker MW, Bottomley SP. Dunstone MA, et al. Among authors: le bonniec bf. Protein Sci. 2000 Feb;9(2):417-20. doi: 10.1110/ps.9.2.417. Protein Sci. 2000. PMID: 10716194 Free PMC article.

9

Interaction of thrombin des-ETW with antithrombin III, the Kunitz inhibitors, thrombomodulin and protein C. Structural link between the autolysis loop and the Tyr-Pro-Pro-Trp insertion of thrombin.

Le Bonniec BF, Guinto ER, Esmon CT. Le Bonniec BF, et al. J Biol Chem. 1992 Sep 25;267(27):19341-8. J Biol Chem. 1992. PMID: 1326550 Free article.

10

Glu192-->Gln substitution in thrombin yields an enzyme that is effectively inhibited by bovine pancreatic trypsin inhibitor and tissue factor pathway inhibitor.

Guinto ER, Ye J, Le Bonniec BF, Esmon CT. Guinto ER, et al. Among authors: le bonniec bf. J Biol Chem. 1994 Jul 15;269(28):18395-400. J Biol Chem. 1994. PMID: 7518431 Free article.

Indeed, deletion of Pro60B, Pro60C, and Trp60D from this loop (des-PPW) enhances BPTI inhibition (Ki = 16 nM) (Le Bonniec, B. F., Guinto, E. R., MacGillivray, R. T. A., Stone, S. R., and Esmon, C. ...

Indeed, deletion of Pro60B, Pro60C, and Trp60D from this loop (des-PPW) enhances BPTI inhibition (Ki = 16 nM) (Le Bonniec, …

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