Cane DE - Search Results

1

Crystal structure of the macrocycle-forming thioesterase domain of the erythromycin polyketide synthase: versatility from a unique substrate channel.

Tsai SC, Miercke LJ, Krucinski J, Gokhale R, Chen JC, Foster PG, Cane DE, Khosla C, Stroud RM. Tsai SC, et al. Among authors: cane de. Proc Natl Acad Sci U S A. 2001 Dec 18;98(26):14808-13. doi: 10.1073/pnas.011399198. Proc Natl Acad Sci U S A. 2001. PMID: 11752428 Free PMC article.

2

The 2.7-Angstrom crystal structure of a 194-kDa homodimeric fragment of the 6-deoxyerythronolide B synthase.

Tang Y, Kim CY, Mathews II, Cane DE, Khosla C. Tang Y, et al. Among authors: cane de. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11124-9. doi: 10.1073/pnas.0601924103. Epub 2006 Jul 14. Proc Natl Acad Sci U S A. 2006. PMID: 16844787 Free PMC article.

3

Insights into channel architecture and substrate specificity from crystal structures of two macrocycle-forming thioesterases of modular polyketide synthases.

Tsai SC, Lu H, Cane DE, Khosla C, Stroud RM. Tsai SC, et al. Among authors: cane de. Biochemistry. 2002 Oct 22;41(42):12598-606. doi: 10.1021/bi0260177. Biochemistry. 2002. PMID: 12379102

4

Functional orientation of the acyltransferase domain in a module of the erythromycin polyketide synthase.

Gokhale RS, Lau J, Cane DE, Khosla C. Gokhale RS, et al. Among authors: cane de. Biochemistry. 1998 Feb 24;37(8):2524-8. doi: 10.1021/bi971887n. Biochemistry. 1998. PMID: 9485401

5

Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase.

Gokhale RS, Hunziker D, Cane DE, Khosla C. Gokhale RS, et al. Among authors: cane de. Chem Biol. 1999 Feb;6(2):117-25. doi: 10.1016/S1074-5521(99)80008-8. Chem Biol. 1999. PMID: 10021418

6

Substrate specificity of the loading didomain of the erythromycin polyketide synthase.

Lau J, Cane DE, Khosla C. Lau J, et al. Among authors: cane de. Biochemistry. 2000 Aug 29;39(34):10514-20. doi: 10.1021/bi000602v. Biochemistry. 2000. PMID: 10956042

7

Structure-based dissociation of a type I polyketide synthase module.

Chen AY, Cane DE, Khosla C. Chen AY, et al. Among authors: cane de. Chem Biol. 2007 Jul;14(7):784-92. doi: 10.1016/j.chembiol.2007.05.015. Chem Biol. 2007. PMID: 17656315 Free PMC article.

8

Solution structure and proposed domain domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase.

Alekseyev VY, Liu CW, Cane DE, Puglisi JD, Khosla C. Alekseyev VY, et al. Among authors: cane de. Protein Sci. 2007 Oct;16(10):2093-107. doi: 10.1110/ps.073011407. Protein Sci. 2007. PMID: 17893358 Free PMC article.

9

Molecular recognition between ketosynthase and acyl carrier protein domains of the 6-deoxyerythronolide B synthase.

Kapur S, Chen AY, Cane DE, Khosla C. Kapur S, et al. Among authors: cane de. Proc Natl Acad Sci U S A. 2010 Dec 21;107(51):22066-71. doi: 10.1073/pnas.1014081107. Epub 2010 Dec 2. Proc Natl Acad Sci U S A. 2010. PMID: 21127271 Free PMC article.

10

Reprogramming a module of the 6-deoxyerythronolide B synthase for iterative chain elongation.

Kapur S, Lowry B, Yuzawa S, Kenthirapalan S, Chen AY, Cane DE, Khosla C. Kapur S, et al. Among authors: cane de. Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4110-5. doi: 10.1073/pnas.1118734109. Epub 2012 Feb 27. Proc Natl Acad Sci U S A. 2012. PMID: 22371562 Free PMC article.

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