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Nitrolinoleate inhibits platelet activation by attenuating calcium mobilization and inducing phosphorylation of vasodilator-stimulated phosphoprotein through elevation of cAMP.
Coles B, Bloodsworth A, Eiserich JP, Coffey MJ, McLoughlin RM, Giddings JC, Lewis MJ, Haslam RJ, Freeman BA, O'Donnell VB. Coles B, et al. Among authors: freeman ba. J Biol Chem. 2002 Feb 22;277(8):5832-40. doi: 10.1074/jbc.M105209200. Epub 2001 Dec 17. J Biol Chem. 2002. PMID: 11748216 Free article.
Myeloperoxidase, a leukocyte-derived vascular NO oxidase.
Eiserich JP, Baldus S, Brennan ML, Ma W, Zhang C, Tousson A, Castro L, Lusis AJ, Nauseef WM, White CR, Freeman BA. Eiserich JP, et al. Among authors: freeman ba. Science. 2002 Jun 28;296(5577):2391-4. doi: 10.1126/science.1106830. Science. 2002. PMID: 12089442
Myeloperoxidase mediates neutrophil activation by association with CD11b/CD18 integrins.
Lau D, Mollnau H, Eiserich JP, Freeman BA, Daiber A, Gehling UM, Brümmer J, Rudolph V, Münzel T, Heitzer T, Meinertz T, Baldus S. Lau D, et al. Among authors: freeman ba. Proc Natl Acad Sci U S A. 2005 Jan 11;102(2):431-6. doi: 10.1073/pnas.0405193102. Epub 2004 Dec 29. Proc Natl Acad Sci U S A. 2005. PMID: 15625114 Free PMC article.
Novel keto-phospholipids are generated by monocytes and macrophages, detected in cystic fibrosis, and activate peroxisome proliferator-activated receptor-γ.
Hammond VJ, Morgan AH, Lauder S, Thomas CP, Brown S, Freeman BA, Lloyd CM, Davies J, Bush A, Levonen AL, Kansanen E, Villacorta L, Chen YE, Porter N, Garcia-Diaz YM, Schopfer FJ, O'Donnell VB. Hammond VJ, et al. Among authors: freeman ba. J Biol Chem. 2012 Dec 7;287(50):41651-66. doi: 10.1074/jbc.M112.405407. Epub 2012 Oct 11. J Biol Chem. 2012. PMID: 23060450 Free PMC article. Clinical Trial.
340 results