Halpert JR - Search Results

1

The genetic determinants of the CYP3A5 polymorphism.

Hustert E, Haberl M, Burk O, Wolbold R, He YQ, Klein K, Nuessler AC, Neuhaus P, Klattig J, Eiselt R, Koch I, Zibat A, Brockmöller J, Halpert JR, Zanger UM, Wojnowski L. Hustert E, et al. Among authors: halpert jr. Pharmacogenetics. 2001 Dec;11(9):773-9. doi: 10.1097/00008571-200112000-00005. Pharmacogenetics. 2001. PMID: 11740341

2

Identification and functional characterization of eight CYP3A4 protein variants.

Eiselt R, Domanski TL, Zibat A, Mueller R, Presecan-Siedel E, Hustert E, Zanger UM, Brockmoller J, Klenk HP, Meyer UA, Khan KK, He YA, Halpert JR, Wojnowski L. Eiselt R, et al. Among authors: halpert jr. Pharmacogenetics. 2001 Jul;11(5):447-58. doi: 10.1097/00008571-200107000-00008. Pharmacogenetics. 2001. PMID: 11470997

3

Importance of amino acid residue 474 for substrate specificity of canine and human cytochrome p450 3A enzymes.

He YQ, Roussel F, Halpert JR. He YQ, et al. Among authors: halpert jr. Arch Biochem Biophys. 2001 May 15;389(2):264-70. doi: 10.1006/abbi.2001.2342. Arch Biochem Biophys. 2001. PMID: 11339816

4

Differential oxidation of mifepristone by cytochromes P450 3A4 and 3A5: selective inactivation of P450 3A4.

Khan KK, He YQ, Correia MA, Halpert JR. Khan KK, et al. Among authors: halpert jr. Drug Metab Dispos. 2002 Sep;30(9):985-90. doi: 10.1124/dmd.30.9.985. Drug Metab Dispos. 2002. PMID: 12167563

5

Use of chimeric enzymes and site-directed mutagenesis for identification of three key residues responsible for differences in steroid hydroxylation between canine cytochromes P-450 3A12 and 3A26.

Fraser DJ, He YQ, Harlow GR, Halpert JR. Fraser DJ, et al. Among authors: halpert jr. Mol Pharmacol. 1999 Feb;55(2):241-7. doi: 10.1124/mol.55.2.241. Mol Pharmacol. 1999. PMID: 9927614

6

Interconversion of the androstenedione hydroxylase specificities of cytochromes P450 2B4 and 2B5 upon simultaneous site-directed mutagenesis of four key substrate recognition residues.

He YQ, Szklarz GD, Halpert JR. He YQ, et al. Among authors: halpert jr. Arch Biochem Biophys. 1996 Nov 1;335(1):152-60. doi: 10.1006/abbi.1996.0493. Arch Biochem Biophys. 1996. PMID: 8914846

7

Structural determinants of progesterone hydroxylation by cytochrome P450 2B5: the role of nonsubstrate recognition site residues.

He YQ, Harlow GR, Szklarz GD, Halpert JR. He YQ, et al. Among authors: halpert jr. Arch Biochem Biophys. 1998 Feb 15;350(2):333-9. doi: 10.1006/abbi.1997.0516. Arch Biochem Biophys. 1998. PMID: 9473309

8

Escherichia coli expression of site-directed mutants of cytochrome P450 2B1 from six substrate recognition sites: substrate specificity and inhibitor selectivity studies.

He YQ, He YA, Halpert JR. He YQ, et al. Among authors: halpert jr. Chem Res Toxicol. 1995 Jun;8(4):574-9. doi: 10.1021/tx00046a011. Chem Res Toxicol. 1995. PMID: 7548737

9

Substrate routes to the buried active site may vary among cytochromes P450: mutagenesis of the F-G region in P450 2B1.

Scott EE, He YQ, Halpert JR. Scott EE, et al. Among authors: halpert jr. Chem Res Toxicol. 2002 Nov;15(11):1407-13. doi: 10.1021/tx020057u. Chem Res Toxicol. 2002. PMID: 12437331

10

Identification of three key residues in substrate recognition site 5 of human cytochrome P450 3A4 by cassette and site-directed mutagenesis.

He YA, He YQ, Szklarz GD, Halpert JR. He YA, et al. Among authors: halpert jr. Biochemistry. 1997 Jul 22;36(29):8831-9. doi: 10.1021/bi970182i. Biochemistry. 1997. PMID: 9220969

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