Yashiro H - Search Results

1

Cibenzoline, an ATP-sensitive K(+) channel blocker, binds to the K(+)-binding site from the cytoplasmic side of gastric H(+),K(+)-ATPase.

Tabuchi Y, Yashiro H, Hoshina S, Asano S, Takeguchi N. Tabuchi Y, et al. Among authors: yashiro h. Br J Pharmacol. 2001 Dec;134(8):1655-62. doi: 10.1038/sj.bjp.0704422. Br J Pharmacol. 2001. PMID: 11739241 Free PMC article.

2

Significance of lysine/glycine cluster structure in gastric H+,K+-ATPase.

Asano S, Miwa K, Yashiro H, Tabuchi Y, Takeguchi N. Asano S, et al. Among authors: yashiro h. Jpn J Physiol. 2000 Aug;50(4):419-28. doi: 10.2170/jjphysiol.50.419. Jpn J Physiol. 2000. PMID: 11082540 Free article.

3

The cavity structure for docking the K(+)-competitive inhibitors in the gastric proton pump.

Asano S, Yoshida A, Yashiro H, Kobayashi Y, Morisato A, Ogawa H, Takeguchi N, Morii M. Asano S, et al. Among authors: yashiro h. J Biol Chem. 2004 Apr 2;279(14):13968-75. doi: 10.1074/jbc.M308934200. Epub 2003 Dec 29. J Biol Chem. 2004. PMID: 14699149 Free article.

4

Design and biological evaluation of imidazo[1,2-a]pyridines as novel and potent ASK1 inhibitors.

Terao Y, Suzuki H, Yoshikawa M, Yashiro H, Takekawa S, Fujitani Y, Okada K, Inoue Y, Yamamoto Y, Nakagawa H, Yao S, Kawamoto T, Uchikawa O. Terao Y, et al. Among authors: yashiro h. Bioorg Med Chem Lett. 2012 Dec 15;22(24):7326-9. doi: 10.1016/j.bmcl.2012.10.084. Epub 2012 Oct 23. Bioorg Med Chem Lett. 2012. PMID: 23147077

5

The effects of TAK-875, a selective G protein-coupled receptor 40/free fatty acid 1 agonist, on insulin and glucagon secretion in isolated rat and human islets.

Yashiro H, Tsujihata Y, Takeuchi K, Hazama M, Johnson PR, Rorsman P. Yashiro H, et al. J Pharmacol Exp Ther. 2012 Feb;340(2):483-9. doi: 10.1124/jpet.111.187708. Epub 2011 Nov 21. J Pharmacol Exp Ther. 2012. PMID: 22106100

6

Design, Synthesis, and Biological Evaluation of a Novel Series of 4-Guanidinobenzoate Derivatives as Enteropeptidase Inhibitors with Low Systemic Exposure for the Treatment of Obesity.

Ikeda Z, Kakegawa K, Kikuchi F, Itono S, Oki H, Yashiro H, Hiyoshi H, Tsuchimori K, Hamagami K, Watanabe M, Sasaki M, Ishihara Y, Tohyama K, Kitazaki T, Maekawa T, Sasaki M. Ikeda Z, et al. Among authors: yashiro h. J Med Chem. 2022 Jun 23;65(12):8456-8477. doi: 10.1021/acs.jmedchem.2c00463. Epub 2022 Jun 10. J Med Chem. 2022. PMID: 35686954 Free PMC article.

7

A Novel Selective Inhibitor of Delta-5 Desaturase Lowers Insulin Resistance and Reduces Body Weight in Diet-Induced Obese C57BL/6J Mice.

Yashiro H, Takagahara S, Tamura YO, Miyahisa I, Matsui J, Suzuki H, Ikeda S, Watanabe M. Yashiro H, et al. PLoS One. 2016 Nov 10;11(11):e0166198. doi: 10.1371/journal.pone.0166198. eCollection 2016. PLoS One. 2016. PMID: 27832159 Free PMC article.

8

Discovery and characterization of a small-molecule enteropeptidase inhibitor, SCO-792.

Sasaki M, Miyahisa I, Itono S, Yashiro H, Hiyoshi H, Tsuchimori K, Hamagami KI, Moritoh Y, Watanabe M, Tohyama K, Sasaki M, Sakamoto JI, Kawamoto T. Sasaki M, et al. Among authors: yashiro h. Pharmacol Res Perspect. 2019 Sep 4;7(5):e00517. doi: 10.1002/prp2.517. eCollection 2019 Oct. Pharmacol Res Perspect. 2019. PMID: 31508234 Free PMC article.

9

Discovery of novel 5-oxa-2,6-diazaspiro[3.4]oct-6-ene derivatives as potent, selective, and orally available somatostatin receptor subtype 5 (SSTR5) antagonists for treatment of type 2 diabetes mellitus.

Hirose H, Yamasaki T, Ogino M, Mizojiri R, Tamura-Okano Y, Yashiro H, Muraki Y, Nakano Y, Sugama J, Hata A, Iwasaki S, Watanabe M, Maekawa T, Kasai S. Hirose H, et al. Among authors: yashiro h. Bioorg Med Chem. 2017 Aug 1;25(15):4175-4193. doi: 10.1016/j.bmc.2017.06.007. Epub 2017 Jun 9. Bioorg Med Chem. 2017. PMID: 28642028

10

Discovery of a 3-pyridylacetic acid derivative (TAK-100) as a potent, selective and orally active dipeptidyl peptidase IV (DPP-4) inhibitor.

Miyamoto Y, Banno Y, Yamashita T, Fujimoto T, Oi S, Moritoh Y, Asakawa T, Kataoka O, Yashiro H, Takeuchi K, Suzuki N, Ikedo K, Kosaka T, Tsubotani S, Tani A, Sasaki M, Funami M, Amano M, Yamamoto Y, Aertgeerts K, Yano J, Maezaki H. Miyamoto Y, et al. Among authors: yashiro h. J Med Chem. 2011 Feb 10;54(3):831-50. doi: 10.1021/jm101236h. Epub 2011 Jan 10. J Med Chem. 2011. PMID: 21218817

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