Han AP - Search Results

1

Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency.

Han AP, Yu C, Lu L, Fujiwara Y, Browne C, Chin G, Fleming M, Leboulch P, Orkin SH, Chen JJ. Han AP, et al. EMBO J. 2001 Dec 3;20(23):6909-18. doi: 10.1093/emboj/20.23.6909. EMBO J. 2001. PMID: 11726526 Free PMC article.

2

Autophosphorylation of threonine 485 in the activation loop is essential for attaining eIF2alpha kinase activity of HRI.

Rafie-Kolpin M, Han AP, Chen JJ. Rafie-Kolpin M, et al. Among authors: han ap. Biochemistry. 2003 Jun 3;42(21):6536-44. doi: 10.1021/bi034005v. Biochemistry. 2003. PMID: 12767237

3

Heme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemia.

Han AP, Fleming MD, Chen JJ. Han AP, et al. J Clin Invest. 2005 Jun;115(6):1562-70. doi: 10.1172/JCI24141. J Clin Invest. 2005. PMID: 15931390 Free PMC article.

4

Translation initiation control by heme-regulated eukaryotic initiation factor 2alpha kinase in erythroid cells under cytoplasmic stresses.

Lu L, Han AP, Chen JJ. Lu L, et al. Among authors: han ap. Mol Cell Biol. 2001 Dec;21(23):7971-80. doi: 10.1128/MCB.21.23.7971-7980.2001. Mol Cell Biol. 2001. PMID: 11689689 Free PMC article.

5

Multiple autophosphorylation is essential for the formation of the active and stable homodimer of heme-regulated eIF2alpha kinase.

Bauer BN, Rafie-Kolpin M, Lu L, Han A, Chen JJ. Bauer BN, et al. Biochemistry. 2001 Sep 25;40(38):11543-51. doi: 10.1021/bi010983s. Biochemistry. 2001. PMID: 11560503

6

The function of heme-regulated eIF2alpha kinase in murine iron homeostasis and macrophage maturation.

Liu S, Suragani RN, Wang F, Han A, Zhao W, Andrews NC, Chen JJ. Liu S, et al. J Clin Invest. 2007 Nov;117(11):3296-305. doi: 10.1172/JCI32084. J Clin Invest. 2007. PMID: 17932563 Free PMC article.

7

Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice.

Liu S, Suragani RN, Han A, Zhao W, Andrews NC, Chen JJ. Liu S, et al. Haematologica. 2008 May;93(5):753-6. doi: 10.3324/haematol.12175. Epub 2008 Mar 26. Haematologica. 2008. PMID: 18367482 Free PMC article.

8

Haem-regulated eIF2alpha kinase is necessary for adaptive gene expression in erythroid precursors under the stress of iron deficiency.

Liu S, Bhattacharya S, Han A, Suragani RN, Zhao W, Fry RC, Chen JJ. Liu S, et al. Br J Haematol. 2008 Oct;143(1):129-37. doi: 10.1111/j.1365-2141.2008.07293.x. Epub 2008 Jul 28. Br J Haematol. 2008. PMID: 18665838 Free PMC article.

9

Heme-regulated inhibitor kinase-mediated phosphorylation of eukaryotic translation initiation factor 2 inhibits translation, induces stress granule formation, and mediates survival upon arsenite exposure.

McEwen E, Kedersha N, Song B, Scheuner D, Gilks N, Han A, Chen JJ, Anderson P, Kaufman RJ. McEwen E, et al. J Biol Chem. 2005 Apr 29;280(17):16925-33. doi: 10.1074/jbc.M412882200. Epub 2005 Jan 31. J Biol Chem. 2005. PMID: 15684421 Free article.

10

The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis.

Pondarré C, Antiochos BB, Campagna DR, Clarke SL, Greer EL, Deck KM, McDonald A, Han AP, Medlock A, Kutok JL, Anderson SA, Eisenstein RS, Fleming MD. Pondarré C, et al. Among authors: han ap. Hum Mol Genet. 2006 Mar 15;15(6):953-64. doi: 10.1093/hmg/ddl012. Epub 2006 Feb 8. Hum Mol Genet. 2006. PMID: 16467350

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