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Discovery of 2-chloro-N-(4-methoxyphenyl)-N-methylquinazolin-4-amine (EP128265, MPI-0441138) as a potent inducer of apoptosis with high in vivo activity.
Sirisoma N, Kasibhatla S, Pervin A, Zhang H, Jiang S, Willardsen JA, Anderson MB, Baichwal V, Mather GG, Jessing K, Hussain R, Hoang K, Pleiman CM, Tseng B, Drewe J, Cai SX. Sirisoma N, et al. Among authors: jiang s. J Med Chem. 2008 Aug 14;51(15):4771-9. doi: 10.1021/jm8003653. Epub 2008 Jul 24. J Med Chem. 2008. PMID: 18651728
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 3. Structure-activity relationships of fused rings at the 7,8-positions.
Kemnitzer W, Drewe J, Jiang S, Zhang H, Zhao J, Crogan-Grundy C, Xu L, Lamothe S, Gourdeau H, Denis R, Tseng B, Kasibhatla S, Cai SX. Kemnitzer W, et al. Among authors: jiang s. J Med Chem. 2007 Jun 14;50(12):2858-64. doi: 10.1021/jm070216c. Epub 2007 May 11. J Med Chem. 2007. PMID: 17497765
Discovery of 4-aryl-4H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high throughput screening assay. 4. Structure-activity relationships of N-alkyl substituted pyrrole fused at the 7,8-positions.
Kemnitzer W, Drewe J, Jiang S, Zhang H, Crogan-Grundy C, Labreque D, Bubenick M, Attardo G, Denis R, Lamothe S, Gourdeau H, Tseng B, Kasibhatla S, Cai SX. Kemnitzer W, et al. Among authors: jiang s. J Med Chem. 2008 Feb 14;51(3):417-23. doi: 10.1021/jm7010657. Epub 2008 Jan 16. J Med Chem. 2008. PMID: 18197614
Discovery of 4-aryl-2-oxo-2H-chromenes as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay.
Kemnitzer W, Jiang S, Zhang H, Kasibhatla S, Crogan-Grundy C, Blais C, Attardo G, Denis R, Lamothe S, Gourdeau H, Tseng B, Drewe J, Cai SX. Kemnitzer W, et al. Among authors: jiang s. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5571-5. doi: 10.1016/j.bmcl.2008.09.011. Epub 2008 Sep 6. Bioorg Med Chem Lett. 2008. PMID: 18805007
Discovery of N-aryl-9-oxo-9H-fluorene-1-carboxamides as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. 1. Structure-activity relationships of the carboxamide group.
Kemnitzer W, Sirisoma N, Nguyen B, Jiang S, Kasibhatla S, Crogan-Grundy C, Tseng B, Drewe J, Cai SX. Kemnitzer W, et al. Among authors: jiang s. Bioorg Med Chem Lett. 2009 Jun 1;19(11):3045-9. doi: 10.1016/j.bmcl.2009.04.009. Epub 2009 Apr 8. Bioorg Med Chem Lett. 2009. PMID: 19394823
Discovery of 1-benzoyl-3-cyanopyrrolo[1,2-a]quinolines as a new series of apoptosis inducers using a cell- and caspase-based high-throughput screening assay. Part 1: Structure-activity relationships of the 1- and 3-positions.
Kemnitzer W, Kuemmerle J, Jiang S, Zhang HZ, Sirisoma N, Kasibhatla S, Crogan-Grundy C, Tseng B, Drewe J, Cai SX. Kemnitzer W, et al. Among authors: jiang s. Bioorg Med Chem Lett. 2008 Dec 1;18(23):6259-64. doi: 10.1016/j.bmcl.2008.09.110. Epub 2008 Oct 17. Bioorg Med Chem Lett. 2008. PMID: 18952423
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