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A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (PPARalpha ) versus liver X receptor.
Thomas J, Bramlett KS, Montrose C, Foxworthy P, Eacho PI, McCann D, Cao G, Kiefer A, McCowan J, Yu KL, Grese T, Chin WW, Burris TP, Michael LF. Thomas J, et al. Among authors: bramlett ks. J Biol Chem. 2003 Jan 24;278(4):2403-10. doi: 10.1074/jbc.M209629200. Epub 2002 Nov 18. J Biol Chem. 2003. PMID: 12441342 Free article.
T0901317 is a dual LXR/FXR agonist.
Houck KA, Borchert KM, Hepler CD, Thomas JS, Bramlett KS, Michael LF, Burris TP. Houck KA, et al. Among authors: bramlett ks. Mol Genet Metab. 2004 Sep-Oct;83(1-2):184-7. doi: 10.1016/j.ymgme.2004.07.007. Mol Genet Metab. 2004. PMID: 15464433
Regulation of carbohydrate metabolism by the farnesoid X receptor.
Stayrook KR, Bramlett KS, Savkur RS, Ficorilli J, Cook T, Christe ME, Michael LF, Burris TP. Stayrook KR, et al. Among authors: bramlett ks. Endocrinology. 2005 Mar;146(3):984-91. doi: 10.1210/en.2004-0965. Epub 2004 Nov 24. Endocrinology. 2005. PMID: 15564327
35 results