Manoharan M - Search Results

1

Antisense properties of 2'-O-dimethylaminooxyethyl (2'-O-DMAOE) oligonucleotides.

Prakash TP, Kawasaki AM, Johnston JF, Graham MJ, Condon TP, Manoharan M. Prakash TP, et al. Among authors: manoharan m. Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):829-32. doi: 10.1081/NCN-100002439. Nucleosides Nucleotides Nucleic Acids. 2001. PMID: 11563125

2

Chemical modifications to improve uptake and bioavailability of antisense oligonucleotides.

Manoharan M, Johnson LK, McGee DP, Guinosso CJ, Ramasamy K, Springer RH, Bennett CF, Ecker DJ, Vickers T, Cowsert L, et al. Manoharan M, et al. Ann N Y Acad Sci. 1992 Oct 28;660:306-9. doi: 10.1111/j.1749-6632.1992.tb21095.x. Ann N Y Acad Sci. 1992. PMID: 1364095 No abstract available.

3

Pharmacokinetic properties of several novel oligonucleotide analogs in mice.

Crooke ST, Graham MJ, Zuckerman JE, Brooks D, Conklin BS, Cummins LL, Greig MJ, Guinosso CJ, Kornbrust D, Manoharan M, Sasmor HM, Schleich T, Tivel KL, Griffey RH. Crooke ST, et al. Among authors: manoharan m. J Pharmacol Exp Ther. 1996 May;277(2):923-37. J Pharmacol Exp Ther. 1996. PMID: 8627575

4

Phosphorothioate oligodeoxyribonucleotides dissociate from cationic lipids before entering the nucleus.

Marcusson EG, Bhat B, Manoharan M, Bennett CF, Dean NM. Marcusson EG, et al. Among authors: manoharan m. Nucleic Acids Res. 1998 Apr 15;26(8):2016-23. doi: 10.1093/nar/26.8.2016. Nucleic Acids Res. 1998. PMID: 9518498 Free PMC article.

5

MMI linkage modification increases potency and stability of H-ras antisense oligonucleotides.

Cowsert LM, Ohashi CT, Bhat B, Peoc'h D, Symons AM, Cook PD, Manoharan M. Cowsert LM, et al. Among authors: manoharan m. Nucleosides Nucleotides. 1999 Jun-Jul;18(6-7):1383-4. doi: 10.1080/07328319908044723. Nucleosides Nucleotides. 1999. PMID: 10474224 No abstract available.

6

Aminooxy functionalized oligonucleotides: preparation, on-support derivatization, and postsynthetic attachment to polymer support.

Salo H, Virta P, Hakala H, Prakash TP, Kawasaki AM, Manoharan M, Lönnberg H. Salo H, et al. Among authors: manoharan m. Bioconjug Chem. 1999 Sep-Oct;10(5):815-23. doi: 10.1021/bc990021m. Bioconjug Chem. 1999. PMID: 10502348

7

2'-carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and conjugation.

Manoharan M. Manoharan M. Biochim Biophys Acta. 1999 Dec 10;1489(1):117-30. doi: 10.1016/s0167-4781(99)00138-4. Biochim Biophys Acta. 1999. PMID: 10807002 Review.

8

Synthesis of chimeric oligonucleotides containing phosphodiester, phosphorothioate, and phosphoramidate linkages.

Maier MA, Guzaev AP, Manoharan M. Maier MA, et al. Among authors: manoharan m. Org Lett. 2000 Jun 29;2(13):1819-22. doi: 10.1021/ol005842h. Org Lett. 2000. PMID: 10891166

9

2'-O-[2-[N,N-(dialkyl)aminooxy]ethyl]-modified antisense oligonucleotides.

Prakash TP, Manoharan M, Kawasaki AM, Lesnik EA, Owens SR, Vasquez G. Prakash TP, et al. Among authors: manoharan m. Org Lett. 2000 Dec 14;2(25):3995-8. doi: 10.1021/ol006555g. Org Lett. 2000. PMID: 11112626

10

Detection of alkali metal ions in DNA crystals using state-of-the-art X-ray diffraction experiments.

Tereshko V, Wilds CJ, Minasov G, Prakash TP, Maier MA, Howard A, Wawrzak Z, Manoharan M, Egli M. Tereshko V, et al. Among authors: manoharan m. Nucleic Acids Res. 2001 Mar 1;29(5):1208-15. doi: 10.1093/nar/29.5.1208. Nucleic Acids Res. 2001. PMID: 11222771 Free PMC article.

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