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A polyamine analogue prevents acute pancreatitis and restores early liver regeneration in transgenic rats with activated polyamine catabolism.
Rasanen TL, Alhonen L, Sinervirta R, Keinanen T, Herzig KH, Suppola S, Khomutov AR, Vepsalainen J, Janne J. Rasanen TL, et al. Among authors: keinanen t. J Biol Chem. 2002 Oct 18;277(42):39867-72. doi: 10.1074/jbc.M205967200. Epub 2002 Aug 13. J Biol Chem. 2002. PMID: 12181316 Free article.
We recently generated a transgenic rat model for acute pancreatitis, which was apparently caused by a massive depletion of pancreatic polyamines spermidine and spermine due to inducible activation of their catabolism (Alhonen, L., Parkkinen, J. J., Keinanen, T., Sin …
We recently generated a transgenic rat model for acute pancreatitis, which was apparently caused by a massive depletion of pancreatic polyam …
Mice with targeted disruption of spermidine/spermine N1-acetyltransferase gene maintain nearly normal tissue polyamine homeostasis but show signs of insulin resistance upon aging.
Niiranen K, Keinänen TA, Pirinen E, Heikkinen S, Tusa M, Fatrai S, Suppola S, Pietilä M, Uimari A, Laakso M, Alhonen L, Jänne J. Niiranen K, et al. J Cell Mol Med. 2006 Oct-Dec;10(4):933-45. doi: 10.1111/j.1582-4934.2006.tb00536.x. J Cell Mol Med. 2006. PMID: 17125596 Free article.
90 results