Cottens S - Search Results

1

Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site.

Weitz-Schmidt G, Welzenbach K, Brinkmann V, Kamata T, Kallen J, Bruns C, Cottens S, Takada Y, Hommel U. Weitz-Schmidt G, et al. Among authors: cottens s. Nat Med. 2001 Jun;7(6):687-92. doi: 10.1038/89058. Nat Med. 2001. PMID: 11385505

2

Structural basis for LFA-1 inhibition upon lovastatin binding to the CD11a I-domain.

Kallen J, Welzenbach K, Ramage P, Geyl D, Kriwacki R, Legge G, Cottens S, Weitz-Schmidt G, Hommel U. Kallen J, et al. Among authors: cottens s. J Mol Biol. 1999 Sep 10;292(1):1-9. doi: 10.1006/jmbi.1999.3047. J Mol Biol. 1999. PMID: 10493852

3

The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation.

Evenou JP, Wagner J, Zenke G, Brinkmann V, Wagner K, Kovarik J, Welzenbach KA, Weitz-Schmidt G, Guntermann C, Towbin H, Cottens S, Kaminski S, Letschka T, Lutz-Nicoladoni C, Gruber T, Hermann-Kleiter N, Thuille N, Baier G. Evenou JP, et al. Among authors: cottens s. J Pharmacol Exp Ther. 2009 Sep;330(3):792-801. doi: 10.1124/jpet.109.153205. Epub 2009 Jun 2. J Pharmacol Exp Ther. 2009. PMID: 19491325

4

Chemical modification of rapamycin: the discovery of SDZ RAD.

Sedrani R, Cottens S, Kallen J, Schuler W. Sedrani R, et al. Among authors: cottens s. Transplant Proc. 1998 Aug;30(5):2192-4. doi: 10.1016/s0041-1345(98)00587-9. Transplant Proc. 1998. PMID: 9723437 No abstract available.

5

Half-filter experiments for assignment, structure determination and hydration analysis of unlabelled ligands bound to 13C/15N labelled proteins.

Dalvit C, Cottens S, Ramage P, Hommel U. Dalvit C, et al. Among authors: cottens s. J Biomol NMR. 1999 Jan;13(1):43-50. doi: 10.1023/A:1008345330011. J Biomol NMR. 1999. PMID: 21080262

6

The immune modulator FTY720 targets sphingosine 1-phosphate receptors.

Brinkmann V, Davis MD, Heise CE, Albert R, Cottens S, Hof R, Bruns C, Prieschl E, Baumruker T, Hiestand P, Foster CA, Zollinger M, Lynch KR. Brinkmann V, et al. Among authors: cottens s. J Biol Chem. 2002 Jun 14;277(24):21453-7. doi: 10.1074/jbc.C200176200. Epub 2002 Apr 19. J Biol Chem. 2002. PMID: 11967257 Free article.

7

FTY720: dissection of membrane receptor-operated, stereospecific effects on cell migration from receptor-independent antiproliferative and apoptotic effects.

Brinkmann V, Wilt C, Kristofic C, Nikolova Z, Hof RP, Chen S, Albert R, Cottens S. Brinkmann V, et al. Among authors: cottens s. Transplant Proc. 2001 Nov-Dec;33(7-8):3078-80. doi: 10.1016/s0041-1345(01)02312-0. Transplant Proc. 2001. PMID: 11750323 No abstract available.

8

Derivation of Rapamycin: Adventures in Natural Product Chemistry.

Cottens S, Kallen J, Schuler W, Sedrani R. Cottens S, et al. Chimia (Aarau). 2019 Aug 21;73(7-8):581-590. doi: 10.2533/chimia.2019.581. Chimia (Aarau). 2019. PMID: 31431218 Free article.

9

Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes.

Wagner J, von Matt P, Sedrani R, Albert R, Cooke N, Ehrhardt C, Geiser M, Rummel G, Stark W, Strauss A, Cowan-Jacob SW, Beerli C, Weckbecker G, Evenou JP, Zenke G, Cottens S. Wagner J, et al. Among authors: cottens s. J Med Chem. 2009 Oct 22;52(20):6193-6. doi: 10.1021/jm901108b. J Med Chem. 2009. PMID: 19827831

10

SDZ RAD, a new rapamycin derivative: pharmacological properties in vitro and in vivo.

Schuler W, Sedrani R, Cottens S, Häberlin B, Schulz M, Schuurman HJ, Zenke G, Zerwes HG, Schreier MH. Schuler W, et al. Among authors: cottens s. Transplantation. 1997 Jul 15;64(1):36-42. doi: 10.1097/00007890-199707150-00008. Transplantation. 1997. PMID: 9233698

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