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2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1.
Chan JH, Hong JS, Hunter RN 3rd, Orr GF, Cowan JR, Sherman DB, Sparks SM, Reitter BE, Andrews CW 3rd, Hazen RJ, St Clair M, Boone LR, Ferris RG, Creech KL, Roberts GB, Short SA, Weaver K, Ott RJ, Ren J, Hopkins A, Stuart DI, Stammers DK. Chan JH, et al. Among authors: hopkins a. J Med Chem. 2001 Jun 7;44(12):1866-82. doi: 10.1021/jm0004906. J Med Chem. 2001. PMID: 11384233
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2.
Freeman GA, Andrews Iii CW 3rd, Hopkins AL, Lowell GS, Schaller LT, Cowan JR, Gonzales SS, Koszalka GW, Hazen RJ, Boone LR, Ferris RG, Creech KL, Roberts GB, Short SA, Weaver K, Reynolds DJ, Milton J, Ren J, Stuart DI, Stammers DK, Chan JH. Freeman GA, et al. Among authors: hopkins al. J Med Chem. 2004 Nov 18;47(24):5923-36. doi: 10.1021/jm040072r. J Med Chem. 2004. PMID: 15537347
Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor.
Esnouf RM, Ren J, Hopkins AL, Ross CK, Jones EY, Stammers DK, Stuart DI. Esnouf RM, et al. Among authors: hopkins al. Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3984-9. doi: 10.1073/pnas.94.8.3984. Proc Natl Acad Sci U S A. 1997. PMID: 9108091 Free PMC article.
825 results