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Page 1
2-Amino-6-arylsulfonylbenzonitriles as non-nucleoside reverse transcriptase inhibitors of HIV-1.
Chan JH, Hong JS, Hunter RN 3rd, Orr GF, Cowan JR, Sherman DB, Sparks SM, Reitter BE, Andrews CW 3rd, Hazen RJ, St Clair M, Boone LR, Ferris RG, Creech KL, Roberts GB, Short SA, Weaver K, Ott RJ, Ren J, Hopkins A, Stuart DI, Stammers DK. Chan JH, et al. Among authors: creech kl. J Med Chem. 2001 Jun 7;44(12):1866-82. doi: 10.1021/jm0004906. J Med Chem. 2001. PMID: 11384233
Novel benzophenones as non-nucleoside reverse transcriptase inhibitors of HIV-1.
Chan JH, Freeman GA, Tidwell JH, Romines KR, Schaller LT, Cowan JR, Gonzales SS, Lowell GS, Andrews CW 3rd, Reynolds DJ, St Clair M, Hazen RJ, Ferris RG, Creech KL, Roberts GB, Short SA, Weaver K, Koszalka GW, Boone LR. Chan JH, et al. Among authors: creech kl. J Med Chem. 2004 Feb 26;47(5):1175-82. doi: 10.1021/jm030255y. J Med Chem. 2004. PMID: 14971897
Design of non-nucleoside inhibitors of HIV-1 reverse transcriptase with improved drug resistance properties. 2.
Freeman GA, Andrews Iii CW 3rd, Hopkins AL, Lowell GS, Schaller LT, Cowan JR, Gonzales SS, Koszalka GW, Hazen RJ, Boone LR, Ferris RG, Creech KL, Roberts GB, Short SA, Weaver K, Reynolds DJ, Milton J, Ren J, Stuart DI, Stammers DK, Chan JH. Freeman GA, et al. Among authors: creech kl. J Med Chem. 2004 Nov 18;47(24):5923-36. doi: 10.1021/jm040072r. J Med Chem. 2004. PMID: 15537347
Discovery of novel urea-based hepatitis C protease inhibitors with high potency against protease-inhibitor-resistant mutants.
Kazmierski WM, Hamatake R, Duan M, Wright LL, Smith GK, Jarvest RL, Ji JJ, Cooper JP, Tallant MD, Crosby RM, Creech K, Wang A, Li X, Zhang S, Zhang YK, Liu Y, Ding CZ, Zhou Y, Plattner JJ, Baker SJ, Bu W, Liu L. Kazmierski WM, et al. J Med Chem. 2012 Apr 12;55(7):3021-6. doi: 10.1021/jm201278q. Epub 2012 Apr 3. J Med Chem. 2012. PMID: 22471376
Design of N-Benzoxaborole Benzofuran GSK8175-Optimization of Human Pharmacokinetics Inspired by Metabolites of a Failed Clinical HCV Inhibitor.
Chong PY, Shotwell JB, Miller J, Price DJ, Maynard A, Voitenleitner C, Mathis A, Williams S, Pouliot JJ, Creech K, Wang F, Fang J, Zhang H, Tai VW, Turner E, Kahler KM, Crosby R, Peat AJ. Chong PY, et al. J Med Chem. 2019 Apr 11;62(7):3254-3267. doi: 10.1021/acs.jmedchem.8b01719. Epub 2019 Mar 7. J Med Chem. 2019. PMID: 30763090 Free PMC article.
Identification of a chemical tool for the orphan nuclear receptor FXR.
Maloney PR, Parks DJ, Haffner CD, Fivush AM, Chandra G, Plunket KD, Creech KL, Moore LB, Wilson JG, Lewis MC, Jones SA, Willson TM. Maloney PR, et al. Among authors: creech kl. J Med Chem. 2000 Aug 10;43(16):2971-4. doi: 10.1021/jm0002127. J Med Chem. 2000. PMID: 10956205 No abstract available.
Pyrazolopyridine antiherpetics: SAR of C2' and C7 amine substituents.
Johns BA, Gudmundsson KS, Turner EM, Allen SH, Samano VA, Ray JA, Freeman GA, Boyd FL Jr, Sexton CJ, Selleseth DW, Creech KL, Moniri KR. Johns BA, et al. Among authors: creech kl. Bioorg Med Chem. 2005 Apr 1;13(7):2397-411. doi: 10.1016/j.bmc.2005.01.044. Bioorg Med Chem. 2005. PMID: 15755642
Conformationally constrained farnesoid X receptor (FXR) agonists: Naphthoic acid-based analogs of GW 4064.
Akwabi-Ameyaw A, Bass JY, Caldwell RD, Caravella JA, Chen L, Creech KL, Deaton DN, Jones SA, Kaldor I, Liu Y, Madauss KP, Marr HB, McFadyen RB, Miller AB, Navas F III, Parks DJ, Spearing PK, Todd D, Williams SP, Wisely GB. Akwabi-Ameyaw A, et al. Among authors: creech kl. Bioorg Med Chem Lett. 2008 Aug 1;18(15):4339-43. doi: 10.1016/j.bmcl.2008.06.073. Epub 2008 Jun 28. Bioorg Med Chem Lett. 2008. PMID: 18621523
29 results