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EDG1 is a functional sphingosine-1-phosphate receptor that is linked via a Gi/o to multiple signaling pathways, including phospholipase C activation, Ca2+ mobilization, Ras-mitogen-activated protein kinase activation, and adenylate cyclase inhibition.
Okamoto H, Takuwa N, Gonda K, Okazaki H, Chang K, Yatomi Y, Shigematsu H, Takuwa Y. Okamoto H, et al. Among authors: gonda k. J Biol Chem. 1998 Oct 16;273(42):27104-10. doi: 10.1074/jbc.273.42.27104. J Biol Chem. 1998. PMID: 9765227 Free article.
Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice.
Wang F, Okamoto Y, Inoki I, Yoshioka K, Du W, Qi X, Takuwa N, Gonda K, Yamamoto Y, Ohkawa R, Nishiuchi T, Sugimoto N, Yatomi Y, Mitsumori K, Asano M, Kinoshita M, Takuwa Y. Wang F, et al. Among authors: gonda k. J Clin Invest. 2010 Nov;120(11):3979-95. doi: 10.1172/JCI42315. Epub 2010 Oct 18. J Clin Invest. 2010. Retraction in: J Clin Invest. 2012 Mar;122(3):1131. doi: 10.1172/jci63366. PMID: 20978351 Free PMC article. Retracted.
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