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Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs.
Soutschek J, Akinc A, Bramlage B, Charisse K, Constien R, Donoghue M, Elbashir S, Geick A, Hadwiger P, Harborth J, John M, Kesavan V, Lavine G, Pandey RK, Racie T, Rajeev KG, Röhl I, Toudjarska I, Wang G, Wuschko S, Bumcrot D, Koteliansky V, Limmer S, Manoharan M, Vornlocher HP. Soutschek J, et al. Nature. 2004 Nov 11;432(7014):173-8. doi: 10.1038/nature03121. Nature. 2004. PMID: 15538359 Free article.
Analysis of mammalian gene function using small interfering RNAs.
Martinez J, Patkaniowska A, Elbashir SM, Harborth J, Hossbach M, Urlaub H, Meyer J, Weber K, Vandenburgh K, Manninga H, Scaringe SA, Luehrmann R, Tuschl T. Martinez J, et al. Among authors: elbashir sm. Nucleic Acids Res Suppl. 2003;(3):333. doi: 10.1093/nass/3.1.333. Nucleic Acids Res Suppl. 2003. PMID: 14510516 No abstract available.
Evaluation of the safety, tolerability and pharmacokinetics of ALN-RSV01, a novel RNAi antiviral therapeutic directed against respiratory syncytial virus (RSV).
DeVincenzo J, Cehelsky JE, Alvarez R, Elbashir S, Harborth J, Toudjarska I, Nechev L, Murugaiah V, Van Vliet A, Vaishnaw AK, Meyers R. DeVincenzo J, et al. Antiviral Res. 2008 Mar;77(3):225-31. doi: 10.1016/j.antiviral.2007.11.009. Epub 2007 Dec 26. Antiviral Res. 2008. PMID: 18242722 Clinical Trial.
42 results