Hayama T - Search Results

1

Crystallographic approach to identification of cyclin-dependent kinase 4 (CDK4)-specific inhibitors by using CDK4 mimic CDK2 protein.

Ikuta M, Kamata K, Fukasawa K, Honma T, Machida T, Hirai H, Suzuki-Takahashi I, Hayama T, Nishimura S. Ikuta M, et al. Among authors: hayama t. J Biol Chem. 2001 Jul 20;276(29):27548-54. doi: 10.1074/jbc.M102060200. Epub 2001 May 2. J Biol Chem. 2001. PMID: 11335721 Free article.

2

Structure-based generation of a new class of potent Cdk4 inhibitors: new de novo design strategy and library design.

Honma T, Hayashi K, Aoyama T, Hashimoto N, Machida T, Fukasawa K, Iwama T, Ikeura C, Ikuta M, Suzuki-Takahashi I, Iwasawa Y, Hayama T, Nishimura S, Morishima H. Honma T, et al. Among authors: hayama t. J Med Chem. 2001 Dec 20;44(26):4615-27. doi: 10.1021/jm0103256. J Med Chem. 2001. PMID: 11741479

3

A novel approach for the development of selective Cdk4 inhibitors: library design based on locations of Cdk4 specific amino acid residues.

Honma T, Yoshizumi T, Hashimoto N, Hayashi K, Kawanishi N, Fukasawa K, Takaki T, Ikeura C, Ikuta M, Suzuki-Takahashi I, Hayama T, Nishimura S, Morishima H. Honma T, et al. Among authors: hayama t. J Med Chem. 2001 Dec 20;44(26):4628-40. doi: 10.1021/jm010326y. J Med Chem. 2001. PMID: 11741480

4

Potent and orally active ET(A) selective antagonists with 5,7-diarylcyclopenteno[1,2-b]pyridine-6-carboxylic acid structures.

Yoshizumi T, Takahashi H, Ohtake N, Jona H, Sato Y, Kishino H, Sakamoto T, Ozaki S, Takahashi H, Shibata Y, Ishii Y, Saito M, Okada M, Hayama T, Nishikibe M. Yoshizumi T, et al. Among authors: hayama t. Bioorg Med Chem. 2004 May 1;12(9):2139-50. doi: 10.1016/j.bmc.2004.02.033. Bioorg Med Chem. 2004. PMID: 15080914

5

6-Carboxy-5,7-diarylcyclopenteno[1,2-b]pyridine derivatives: a novel class of endothelin receptor antagonists.

Niiyama K, Mase T, Takahashi H, Naya A, Katsuki K, Nagase T, Ito S, Hayama T, Hisaka A, Ozaki S, Ihara M, Yano M, Fukuroda T, Noguchi K, Nishikibe M, Ishikawa K. Niiyama K, et al. Among authors: hayama t. Bioorg Med Chem. 2002 Aug;10(8):2461-70. doi: 10.1016/s0968-0896(02)00122-0. Bioorg Med Chem. 2002. PMID: 12057635

6

Structure-activity relationships of cyclic pentapeptide endothelin A receptor antagonists.

Fukami T, Nagase T, Fujita K, Hayama T, Niiyama K, Mase T, Nakajima S, Fukuroda T, Saeki T, Nishikibe M, et al. Fukami T, et al. Among authors: hayama t. J Med Chem. 1995 Oct 13;38(21):4309-24. doi: 10.1021/jm00021a021. J Med Chem. 1995. PMID: 7473559

7

Structure-activity relationships of a novel class of endothelin receptor selective antagonists; 6-carboxy-2-isopropylamino-5,7-diarylcyclopenteno[1,2-b]pyridines.

Takahashi H, Ohtake N, Sakamoto T, Iino T, Kawanishi N, Nakamura M, Yoshizumi T, Niiyama K, Ozaki S, Okada H, Kano A, Takahashi H, Ishii Y, Okada M, Saito M, Sawazaki Y, Hayama T, Nishikibe M. Takahashi H, et al. Among authors: hayama t. Bioorg Med Chem Lett. 2004 Mar 22;14(6):1503-7. doi: 10.1016/j.bmcl.2004.01.008. Bioorg Med Chem Lett. 2004. PMID: 15006391

8

A convenient synthetic method of a 5,7-diarylcyclopenteno-[1,2-b]pyridine-6-carboxylate: a key intermediate for potent endothelin receptor antagonists.

Niiyama K, Yoshizumi T, Takahashi H, Naya A, Ohtake N, Fukami T, Mase T, Hayama T, Ishikawa K. Niiyama K, et al. Among authors: hayama t. Bioorg Med Chem. 2002 Nov;10(11):3437-44. doi: 10.1016/s0968-0896(02)00261-4. Bioorg Med Chem. 2002. PMID: 12213457

9

Marked reduction of mortality in salt-loaded Dahl salt-sensitive rats by the new, selective endothelin ETA receptor antagonist, J-105859.

Okada M, Nishino M, Saito M, Ikeda T, Uehara S, Okada H, Niiyama K, Ohtake N, Hayama T, Nishikibe M. Okada M, et al. Among authors: hayama t. J Hypertens. 2000 Dec;18(12):1815-23. doi: 10.1097/00004872-200018120-00016. J Hypertens. 2000. PMID: 11132606

10

Cyclic pentapeptide endothelin antagonists with high ETA selectivity. Potency- and solubility-enhancing modifications.

Ishikawa K, Fukami T, Nagase T, Fujita K, Hayama T, Niiyama K, Mase T, Ihara M, Yano M. Ishikawa K, et al. Among authors: hayama t. J Med Chem. 1992 May 29;35(11):2139-42. doi: 10.1021/jm00089a028. J Med Chem. 1992. PMID: 1317926 No abstract available.

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