Hammond PS - Search Results

1

Synthesis of 2beta-acyl-3beta-(substituted naphthyl)-8-azabicyclo[3.2.1]octanes and their binding affinities at dopamine and serotonin transport sites.

Davies HM, Gilliatt V, Kuhn LA, Saikali E, Ren P, Hammond PS, Sexton T, Childers SR. Davies HM, et al. Among authors: hammond ps. J Med Chem. 2001 May 10;44(10):1509-15. doi: 10.1021/jm000363+. J Med Chem. 2001. PMID: 11334561

2

Synthesis and quantitative structure-activity relationships of N-(1-benzylpiperidin-4-yl)phenylacetamides and related analogues as potent and selective sigma1 receptor ligands.

Huang Y, Hammond PS, Whirrett BR, Kuhner RJ, Wu L, Childers SR, Mach RH. Huang Y, et al. Among authors: hammond ps. J Med Chem. 1998 Jun 18;41(13):2361-70. doi: 10.1021/jm980032l. J Med Chem. 1998. PMID: 9632369

3

Synthesis and structure-activity relationships of N-(1-benzylpiperidin-4-yl)arylacetamide analogues as potent sigma1 receptor ligands.

Huang Y, Hammond PS, Wu L, Mach RH. Huang Y, et al. Among authors: hammond ps. J Med Chem. 2001 Dec 6;44(25):4404-15. doi: 10.1021/jm010384j. J Med Chem. 2001. PMID: 11728186

4

Discovery of 3-(5-chloro-2-furoyl)-3,7-diazabicyclo[3.3.0]octane (TC-6683, AZD1446), a novel highly selective α4β2 nicotinic acetylcholine receptor agonist for the treatment of cognitive disorders.

Mazurov AA, Miao L, Bhatti BS, Strachan JP, Akireddy S, Murthy S, Kombo D, Xiao YD, Hammond P, Zhang J, Hauser TA, Jordan KG, Miller CH, Speake JD, Gatto GJ, Yohannes D. Mazurov AA, et al. J Med Chem. 2012 Nov 8;55(21):9181-94. doi: 10.1021/jm3006542. Epub 2012 Jul 27. J Med Chem. 2012. PMID: 22793665

5

Discovery of novel α7 nicotinic acetylcholine receptor ligands via pharmacophoric and docking studies of benzylidene anabaseine analogs.

Kombo DC, Mazurov AA, Chewning J, Hammond PS, Tallapragada K, Hauser TA, Speake J, Yohannes D, Caldwell WS. Kombo DC, et al. Among authors: hammond ps. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1179-86. doi: 10.1016/j.bmcl.2011.11.090. Epub 2011 Nov 30. Bioorg Med Chem Lett. 2012. PMID: 22177081

6

Discovery of (2S,3R)-N-[2-(pyridin-3-ylmethyl)-1-azabicyclo[2.2.2]oct-3-yl]benzo[b]furan-2-carboxamide (TC-5619), a selective α7 nicotinic acetylcholine receptor agonist, for the treatment of cognitive disorders.

Mazurov AA, Kombo DC, Hauser TA, Miao L, Dull G, Genus JF, Fedorov NB, Benson L, Sidach S, Xiao Y, Hammond PS, James JW, Miller CH, Yohannes D. Mazurov AA, et al. Among authors: hammond ps. J Med Chem. 2012 Nov 26;55(22):9793-809. doi: 10.1021/jm301048a. Epub 2012 Nov 13. J Med Chem. 2012. PMID: 23126648

7

Docking studies of benzylidene anabaseine interactions with α7 nicotinic acetylcholine receptor (nAChR) and acetylcholine binding proteins (AChBPs): application to the design of related α7 selective ligands.

Kombo DC, Mazurov A, Tallapragada K, Hammond PS, Chewning J, Hauser TA, Vasquez-Valdivieso M, Yohannes D, Talley TT, Taylor P, Caldwell WS. Kombo DC, et al. Among authors: hammond ps. Eur J Med Chem. 2011 Nov;46(11):5625-35. doi: 10.1016/j.ejmech.2011.09.033. Epub 2011 Sep 29. Eur J Med Chem. 2011. PMID: 21986237 Free PMC article.

8

Analgesic effects mediated by neuronal nicotinic acetylcholine receptor agonists: correlation with desensitization of α4β2* receptors.

Zhang J, Xiao YD, Jordan KG, Hammond PS, Van Dyke KM, Mazurov AA, Speake JD, Lippiello PM, James JW, Letchworth SR, Bencherif M, Hauser TA. Zhang J, et al. Among authors: hammond ps. Eur J Pharm Sci. 2012 Dec 18;47(5):813-23. doi: 10.1016/j.ejps.2012.09.014. Epub 2012 Oct 2. Eur J Pharm Sci. 2012. PMID: 23036283

9

Multiple interaction regions in the orthosteric ligand binding domain of the α7 neuronal nicotinic acetylcholine receptor.

Xiao Y, Hammond PS, Mazurov AA, Yohannes D. Xiao Y, et al. Among authors: hammond ps. J Chem Inf Model. 2012 Nov 26;52(11):3064-73. doi: 10.1021/ci3001953. Epub 2012 Nov 6. J Chem Inf Model. 2012. PMID: 23092444

10

Protonation-induced stereoisomerism in nicotine: conformational studies using classical (AMBER) and ab initio (Car-Parrinello) molecular dynamics.

Hammond PS, Wu Y, Harris R, Minehardt TJ, Car R, Schmitt JD. Hammond PS, et al. J Comput Aided Mol Des. 2005 Jan;19(1):1-15. doi: 10.1007/s10822-005-0096-7. J Comput Aided Mol Des. 2005. PMID: 16059663

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