Rohr J - Search Results

1

Identification of a sugar flexible glycosyltransferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin.

Blanco G, Patallo EP, Braña AF, Trefzer A, Bechthold A, Rohr J, Méndez C, Salas JA. Blanco G, et al. Among authors: rohr j. Chem Biol. 2001 Mar;8(3):253-63. doi: 10.1016/s1074-5521(01)00010-2. Chem Biol. 2001. PMID: 11306350

2

The biosynthetic gene cluster for the antitumor rebeccamycin: characterization and generation of indolocarbazole derivatives.

Sánchez C, Butovich IA, Braña AF, Rohr J, Méndez C, Salas JA. Sánchez C, et al. Among authors: rohr j. Chem Biol. 2002 Apr;9(4):519-31. doi: 10.1016/s1074-5521(02)00126-6. Chem Biol. 2002. PMID: 11983340

3

Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs.

Menéndez N, Nur-e-Alam M, Braña AF, Rohr J, Salas JA, Méndez C. Menéndez N, et al. Among authors: rohr j. Chem Biol. 2004 Jan;11(1):21-32. doi: 10.1016/j.chembiol.2003.12.011. Chem Biol. 2004. PMID: 15112992 Free article.

4

Engineering biosynthetic pathways for deoxysugars: branched-chain sugar pathways and derivatives from the antitumor tetracenomycin.

Lombó F, Gibson M, Greenwell L, Braña AF, Rohr J, Salas JA, Méndez C. Lombó F, et al. Among authors: rohr j. Chem Biol. 2004 Dec;11(12):1709-18. doi: 10.1016/j.chembiol.2004.10.007. Chem Biol. 2004. PMID: 15610855

5

Combining sugar biosynthesis genes for the generation of L- and D-amicetose and formation of two novel antitumor tetracenomycins.

Pérez M, Lombó F, Zhu L, Gibson M, Braña AF, Rohr J, Salas JA, Méndez C. Pérez M, et al. Among authors: rohr j. Chem Commun (Camb). 2005 Mar 28;(12):1604-6. doi: 10.1039/b417815g. Epub 2005 Jan 27. Chem Commun (Camb). 2005. PMID: 15770274

6

Deciphering the late steps in the biosynthesis of the anti-tumour indolocarbazole staurosporine: sugar donor substrate flexibility of the StaG glycosyltransferase.

Salas AP, Zhu L, Sánchez C, Braña AF, Rohr J, Méndez C, Salas JA. Salas AP, et al. Among authors: rohr j. Mol Microbiol. 2005 Oct;58(1):17-27. doi: 10.1111/j.1365-2958.2005.04777.x. Mol Microbiol. 2005. PMID: 16164546 Free PMC article.

7

Combinatorial biosynthesis of antitumor deoxysugar pathways in Streptomyces griseus: Reconstitution of "unnatural natural gene clusters" for the biosynthesis of four 2,6-D-dideoxyhexoses.

Pérez M, Lombó F, Baig I, Braña AF, Rohr J, Salas JA, Méndez C. Pérez M, et al. Among authors: rohr j. Appl Environ Microbiol. 2006 Oct;72(10):6644-52. doi: 10.1128/AEM.01266-06. Appl Environ Microbiol. 2006. PMID: 17021216 Free PMC article.

8

Biosynthesis of elloramycin in Streptomyces olivaceus requires glycosylation by enzymes encoded outside the aglycon cluster.

Ramos A, Lombó F, Braña AF, Rohr J, Méndez C, Salas JA. Ramos A, et al. Among authors: rohr j. Microbiology (Reading). 2008 Mar;154(Pt 3):781-788. doi: 10.1099/mic.0.2007/014035-0. Microbiology (Reading). 2008. PMID: 18310024 Free article.

9

Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis.

Pérez M, Baig I, Braña AF, Salas JA, Rohr J, Méndez C. Pérez M, et al. Among authors: rohr j. Chembiochem. 2008 Sep 22;9(14):2295-304. doi: 10.1002/cbic.200800299. Chembiochem. 2008. PMID: 18756551 Free PMC article.

10

Elucidation of oxygenation steps during oviedomycin biosynthesis and generation of derivatives with increased antitumor activity.

Lombó F, Abdelfattah MS, Braña AF, Salas JA, Rohr J, Méndez C. Lombó F, et al. Among authors: rohr j. Chembiochem. 2009 Jan 26;10(2):296-303. doi: 10.1002/cbic.200800425. Chembiochem. 2009. PMID: 18988223 Free PMC article.

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