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In resting COS1 cells a dominant negative approach shows that specific, anchored PDE4 cAMP phosphodiesterase isoforms gate the activation, by basal cyclic AMP production, of AKAP-tethered protein kinase A type II located in the centrosomal region.
McCahill A, McSorley T, Huston E, Hill EV, Lynch MJ, Gall I, Keryer G, Lygren B, Tasken K, van Heeke G, Houslay MD. McCahill A, et al. Among authors: houslay md. Cell Signal. 2005 Sep;17(9):1158-73. doi: 10.1016/j.cellsig.2005.04.003. Cell Signal. 2005. PMID: 15905070
EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation.
Huston E, Lynch MJ, Mohamed A, Collins DM, Hill EV, MacLeod R, Krause E, Baillie GS, Houslay MD. Huston E, et al. Among authors: houslay md. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12791-6. doi: 10.1073/pnas.0805167105. Epub 2008 Aug 26. Proc Natl Acad Sci U S A. 2008. PMID: 18728186 Free PMC article.
Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ.
Perino A, Ghigo A, Ferrero E, Morello F, Santulli G, Baillie GS, Damilano F, Dunlop AJ, Pawson C, Walser R, Levi R, Altruda F, Silengo L, Langeberg LK, Neubauer G, Heymans S, Lembo G, Wymann MP, Wetzker R, Houslay MD, Iaccarino G, Scott JD, Hirsch E. Perino A, et al. Among authors: houslay md. Mol Cell. 2011 Apr 8;42(1):84-95. doi: 10.1016/j.molcel.2011.01.030. Mol Cell. 2011. PMID: 21474070 Free PMC article.
413 results