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Increased insulin sensitivity in Gsalpha knockout mice.
Yu S, Castle A, Chen M, Lee R, Takeda K, Weinstein LS. Yu S, et al. J Biol Chem. 2001 Jun 8;276(23):19994-8. doi: 10.1074/jbc.M010313200. Epub 2001 Mar 27. J Biol Chem. 2001. PMID: 11274197 Free article.
Mutagenesis of the conserved residue Glu259 of Gsalpha demonstrates the importance of interactions between switches 2 and 3 for activation.
Warner DR, Romanowski R, Yu S, Weinstein LS. Warner DR, et al. Among authors: yu s. J Biol Chem. 1999 Feb 19;274(8):4977-84. doi: 10.1074/jbc.274.8.4977. J Biol Chem. 1999. PMID: 9988742 Free article.
We previously reported that substitution of Arg258 within the switch 3 region of Gsalpha impaired activation and increased basal GDP release due to loss of an interaction between the helical and GTPase domains (Warner, D. R., Weng, G., Yu, S., Matalon, R., and Weins …
We previously reported that substitution of Arg258 within the switch 3 region of Gsalpha impaired activation and increased basal GDP release …
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