Halley F - Search Results

1

RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency.

Collis AJ, Foster ML, Halley F, Maslen C, McLay IM, Page KM, Redford EJ, Souness JE, Wilsher NE. Collis AJ, et al. Among authors: halley f. Bioorg Med Chem Lett. 2001 Mar 12;11(5):693-6. doi: 10.1016/s0960-894x(01)00034-8. Bioorg Med Chem Lett. 2001. PMID: 11266171

2

The discovery of RPR 200765A, a p38 MAP kinase inhibitor displaying a good oral anti-arthritic efficacy.

Mclay LM, Halley F, Souness JE, McKenna J, Benning V, Birrell M, Burton B, Belvisi M, Collis A, Constan A, Foster M, Hele D, Jayyosi Z, Kelley M, Maslen C, Miller G, Ouldelhkim MC, Page K, Phipps S, Pollock K, Porter B, Ratcliffe AJ, Redford EJ, Webber S, Slater B, Thybaud V, Wilsher N. Mclay LM, et al. Among authors: halley f. Bioorg Med Chem. 2001 Feb;9(2):537-54. doi: 10.1016/s0968-0896(00)00331-x. Bioorg Med Chem. 2001. PMID: 11249145

3

An algorithm-directed two-component library synthesized via solid-phase methodology yielding potent and orally bioavailable p38 MAP kinase inhibitors.

McKenna JM, Halley F, Souness JE, McLay IM, Pickett SD, Collis AJ, Page K, Ahmed I. McKenna JM, et al. Among authors: halley f. J Med Chem. 2002 May 23;45(11):2173-84. doi: 10.1021/jm011132l. J Med Chem. 2002. PMID: 12014955

4

Selective endothelin A receptor antagonists. 4. Discovery and structure-activity relationships of stilbene acid and alcohol derivatives.

Astles PC, Brown TJ, Halley F, Handscombe CM, Harris NV, McCarthy C, McLay IM, Lockey P, Majid T, Porter B, Roach AG, Smith C, Walsh R. Astles PC, et al. Among authors: halley f. J Med Chem. 1998 Jul 16;41(15):2745-53. doi: 10.1021/jm970847e. J Med Chem. 1998. PMID: 9667965

5

Identification of a non peptidic RANTES antagonist.

Bright C, Brown TJ, Cox P, Halley F, Lockey P, McLay IM, Moore U, Porter B, Williams RJ. Bright C, et al. Among authors: halley f. Bioorg Med Chem Lett. 1998 Apr 7;8(7):771-4. doi: 10.1016/s0960-894x(98)00094-8. Bioorg Med Chem Lett. 1998. PMID: 9871539

6

Selective ET(A) antagonists. 5. Discovery and structure-activity relationships of phenoxyphenylacetic acid derivatives.

Astles PC, Brown TJ, Halley F, Handscombe CM, Harris NV, Majid TN, McCarthy C, McLay IM, Morley A, Porter B, Roach AG, Sargent C, Smith C, Walsh RJ. Astles PC, et al. Among authors: halley f. J Med Chem. 2000 Mar 9;43(5):900-10. doi: 10.1021/jm990378b. J Med Chem. 2000. PMID: 10715156

7

Potential of p38 inhibitors in the treatment of rheumatoid arthritis.

Foster ML, Halley F, Souness JE. Foster ML, et al. Among authors: halley f. Drug News Perspect. 2000 Oct;13(8):488-97. Drug News Perspect. 2000. PMID: 12937622

8

Design of potent and selective GSK3beta inhibitors with acceptable safety profile and pharmacokinetics.

Lesuisse D, Tiraboschi G, Krick A, Abecassis PY, Dutruc-Rosset G, Babin D, Halley F, Châtreau F, Lachaud S, Chevalier A, Quarteronet D, Burgevin MC, Amara C, Bertrand P, Rooney T. Lesuisse D, et al. Among authors: halley f. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2344-9. doi: 10.1016/j.bmcl.2010.01.132. Epub 2010 Feb 2. Bioorg Med Chem Lett. 2010. PMID: 20189807

9

New low-density lipoprotein receptor upregulators acting via a novel mechanism.

Ashton MJ, Brown TJ, Fenton G, Halley F, Harper MF, Lockey PM, Porter B, Roach AG, Stuttle KA, Vicker N, Walsh RJ. Ashton MJ, et al. Among authors: halley f. J Med Chem. 1996 Aug 16;39(17):3343-56. doi: 10.1021/jm960153q. J Med Chem. 1996. PMID: 8765518

10

Rational design of potent GSK3beta inhibitors with selectivity for Cdk1 and Cdk2.

Lesuisse D, Dutruc-Rosset G, Tiraboschi G, Dreyer MK, Maignan S, Chevalier A, Halley F, Bertrand P, Burgevin MC, Quarteronet D, Rooney T. Lesuisse D, et al. Among authors: halley f. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1985-9. doi: 10.1016/j.bmcl.2010.01.114. Epub 2010 Jan 25. Bioorg Med Chem Lett. 2010. PMID: 20167481

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