Bacha P - Search Results

1

Pivotal phase III trial of two dose levels of denileukin diftitox for the treatment of cutaneous T-cell lymphoma.

Olsen E, Duvic M, Frankel A, Kim Y, Martin A, Vonderheid E, Jegasothy B, Wood G, Gordon M, Heald P, Oseroff A, Pinter-Brown L, Bowen G, Kuzel T, Fivenson D, Foss F, Glode M, Molina A, Knobler E, Stewart S, Cooper K, Stevens S, Craig F, Reuben J, Bacha P, Nichols J. Olsen E, et al. Among authors: bacha p. J Clin Oncol. 2001 Jan 15;19(2):376-88. doi: 10.1200/JCO.2001.19.2.376. J Clin Oncol. 2001. PMID: 11208829 Clinical Trial.

2

Quality-of-life improvements in cutaneous T-cell lymphoma patients treated with denileukin diftitox (ONTAK).

Duvic M, Kuzel TM, Olsen EA, Martin AG, Foss FM, Kim YH, Heald PW, Bacha P, Nichols J, Liepa A. Duvic M, et al. Among authors: bacha p. Clin Lymphoma. 2002 Mar;2(4):222-8. doi: 10.3816/clm.2002.n.003. Clin Lymphoma. 2002. PMID: 11970761 Clinical Trial.

3

Biological correlates of acute hypersensitivity events with DAB(389)IL-2 (denileukin diftitox, ONTAK) in cutaneous T-cell lymphoma: decreased frequency and severity with steroid premedication.

Foss FM, Bacha P, Osann KE, Demierre MF, Bell T, Kuzel T. Foss FM, et al. Among authors: bacha p. Clin Lymphoma. 2001 Mar;1(4):298-302. doi: 10.3816/clm.2001.n.005. Clin Lymphoma. 2001. PMID: 11707845 Clinical Trial.

4

A multicenter dose-escalation trial with denileukin diftitox (ONTAK, DAB(389)IL-2) in patients with severe psoriasis.

Martin A, Gutierrez E, Muglia J, McDonald CJ, Guzzo C, Gottlieb A, Pappert A, Garland WT, Bagel J, Bacha P. Martin A, et al. Among authors: bacha p. J Am Acad Dermatol. 2001 Dec;45(6):871-81. doi: 10.1067/mjd.2001.117852. J Am Acad Dermatol. 2001. PMID: 11712032 Clinical Trial.

5

Anti-arthritic effects demonstrated by an interleukin-2 receptor-targeted cytotoxin (DAB486IL-2) in rat adjuvant arthritis.

Bacha P, Forte SE, Perper SJ, Trentham DE, Nichols JC. Bacha P, et al. Eur J Immunol. 1992 Jul;22(7):1673-9. doi: 10.1002/eji.1830220702. Eur J Immunol. 1992. PMID: 1623918

6

Impact of interleukin-2-receptor-targeted cytotoxins on a unique model of murine interleukin-2-receptor-expressing malignancy.

Bacha PA, Forte SE, McCarthy DM, Estis L, Yamada G, Nichols JC. Bacha PA, et al. Int J Cancer. 1991 Aug 19;49(1):96-101. doi: 10.1002/ijc.2910490118. Int J Cancer. 1991. PMID: 1874577

7

Prevention of smooth muscle cell outgrowth from human atherosclerotic plaque by a recombinant cytotoxin specific for the epidermal growth factor receptor.

Pickering JG, Bacha PA, Weir L, Jekanowski J, Nichols JC, Isner JM. Pickering JG, et al. Among authors: bacha pa. J Clin Invest. 1993 Feb;91(2):724-9. doi: 10.1172/JCI116254. J Clin Invest. 1993. PMID: 8432873 Free PMC article.

8

In vivo studies with chimeric toxins. Interleukin-2 fusion toxins as immunosuppressive agents.

Shapiro ME, Kirkman RL, Kelley VR, Bacha P, Nichols JC, Strom TB. Shapiro ME, et al. Among authors: bacha p. Targeted Diagn Ther. 1992;7:383-93. Targeted Diagn Ther. 1992. PMID: 1633300 Review. No abstract available.

9

Pharmacokinetics of the recombinant fusion protein DAB486IL-2 in animal models.

Bacha P, Forte S, Kassam N, Thomas J, Akiyoshi D, Waters C, Nichols J, Rosenblum M. Bacha P, et al. Cancer Chemother Pharmacol. 1990;26(6):409-14. doi: 10.1007/BF02994090. Cancer Chemother Pharmacol. 1990. PMID: 2225311

10

Interleukin 2-diphtheria toxin fusion protein can abolish cell-mediated immunity in vivo.

Kelley VE, Bacha P, Pankewycz O, Nichols JC, Murphy JR, Strom TB. Kelley VE, et al. Among authors: bacha p. Proc Natl Acad Sci U S A. 1988 Jun;85(11):3980-4. doi: 10.1073/pnas.85.11.3980. Proc Natl Acad Sci U S A. 1988. PMID: 3131768 Free PMC article.

A hybrid IL-2-toxin gene was constructed from the diphtheria toxin gene by replacing the DNA encoding the diphtheria toxin receptor-binding domain with the DNA encoding the receptor-binding domain of IL-2, and the fusion protein encoded by the hybrid gene was expressed in Escheri …

A hybrid IL-2-toxin gene was constructed from the diphtheria toxin gene by replacing the DNA encoding the diphtheria toxin receptor-binding …

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