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Page 1
Broad spectrum antiprotozoal agents that inhibit histone deacetylase: structure-activity relationships of apicidin. Part 1.
Colletti SL, Myers RW, Darkin-Rattray SJ, Gurnett AM, Dulski PM, Galuska S, Allocco JJ, Ayer MB, Li C, Lim J, Crumley TM, Cannova C, Schmatz DM, Wyvratt MJ, Fisher MH, Meinke PT. Colletti SL, et al. Among authors: schmatz dm. Bioorg Med Chem Lett. 2001 Jan 22;11(2):107-11. doi: 10.1016/s0960-894x(00)00604-1. Bioorg Med Chem Lett. 2001. PMID: 11206438
Hydroxylated N-alkyl-4-piperidinyl-2,3-diarylpyrrole derivatives as potent broad-spectrum anticoccidial agents.
Liang GB, Qian X, Biftu T, Feng D, Fisher M, Crumley T, Darkin-Rattray SJ, Dulski PM, Gurnett A, Leavitt PS, Liberator PA, Misura AS, Samaras S, Tamas T, Schmatz DM, Wyvratt M. Liang GB, et al. Among authors: schmatz dm. Bioorg Med Chem Lett. 2005 Oct 15;15(20):4570-3. doi: 10.1016/j.bmcl.2005.06.096. Bioorg Med Chem Lett. 2005. PMID: 16087336
Synthesis and SAR studies of very potent imidazopyridine antiprotozoal agents.
Biftu T, Feng D, Fisher M, Liang GB, Qian X, Scribner A, Dennis R, Lee S, Liberator PA, Brown C, Gurnett A, Leavitt PS, Thompson D, Mathew J, Misura A, Samaras S, Tamas T, Sina JF, McNulty KA, McKnight CG, Schmatz DM, Wyvratt M. Biftu T, et al. Among authors: schmatz dm. Bioorg Med Chem Lett. 2006 May 1;16(9):2479-83. doi: 10.1016/j.bmcl.2006.01.092. Epub 2006 Feb 7. Bioorg Med Chem Lett. 2006. PMID: 16464591
Synthesis and SAR studies of diarylpyrrole anticoccidial agents.
Qian X, Liang GB, Feng D, Fisher M, Crumley T, Rattray S, Dulski PM, Gurnett A, Leavitt PS, Liberator PA, Misura AS, Samaras S, Tamas T, Schmatz DM, Wyvratt M, Biftu T. Qian X, et al. Among authors: schmatz dm. Bioorg Med Chem Lett. 2006 May 15;16(10):2817-21. doi: 10.1016/j.bmcl.2006.01.041. Epub 2006 Mar 6. Bioorg Med Chem Lett. 2006. PMID: 16517161
N-alkyl-4-piperidinyl-2,3-diarylpyrrole derivatives with heterocyclic substitutions as potent and broad spectrum anticoccidial agents.
Liang GB, Qian X, Feng D, Fisher M, Crumley T, Darkin-Rattray SJ, Dulski PM, Gurnett A, Leavitt PS, Liberator PA, Misura AS, Samaras S, Tamas T, Schmatz DM, Wyvratt M, Biftu T. Liang GB, et al. Among authors: schmatz dm. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2019-22. doi: 10.1016/j.bmcl.2008.01.104. Epub 2008 Feb 2. Bioorg Med Chem Lett. 2008. PMID: 18276140
Nodulisporic acid side-chain modifications: access to the 2", 3", 4", and 6" registers.
Chakravarty PK, Shih TL, Colletti SL, Ayer MB, Snedden C, Kuo H, Tyagarajan S, Gregory L, Zakson-Aiken M, Shoop WL, Schmatz DM, Wyvratt M, Fisher MH, Meinke PT. Chakravarty PK, et al. Among authors: schmatz dm. Bioorg Med Chem Lett. 2003 Jan 6;13(1):147-50. doi: 10.1016/s0960-894x(02)00826-0. Bioorg Med Chem Lett. 2003. PMID: 12467636
Synthesis and SAR of 2,3-diarylpyrrole inhibitors of parasite cGMP-dependent protein kinase as novel anticoccidial agents.
Biftu T, Feng D, Ponpipom M, Girotra N, Liang GB, Qian X, Bugianesi R, Simeone J, Chang L, Gurnett A, Liberator P, Dulski P, Leavitt PS, Crumley T, Misura A, Murphy T, Rattray S, Samaras S, Tamas T, Mathew J, Brown C, Thompson D, Schmatz D, Fisher M, Wyvratt M. Biftu T, et al. Bioorg Med Chem Lett. 2005 Jul 1;15(13):3296-301. doi: 10.1016/j.bmcl.2005.04.060. Bioorg Med Chem Lett. 2005. PMID: 15922595
Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase.
Darkin-Rattray SJ, Gurnett AM, Myers RW, Dulski PM, Crumley TM, Allocco JJ, Cannova C, Meinke PT, Colletti SL, Bednarek MA, Singh SB, Goetz MA, Dombrowski AW, Polishook JD, Schmatz DM. Darkin-Rattray SJ, et al. Among authors: schmatz dm. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13143-7. doi: 10.1073/pnas.93.23.13143. Proc Natl Acad Sci U S A. 1996. PMID: 8917558 Free PMC article.
89 results