Crooke R - Search Results

1

Absolute bioavailability of 2'-O-(2-methoxyethyl)-modified antisense oligonucleotides following intraduodenal instillation in rats.

Geary RS, Khatsenko O, Bunker K, Crooke R, Moore M, Burckin T, Truong L, Sasmor H, Levin AA. Geary RS, et al. Among authors: crooke r. J Pharmacol Exp Ther. 2001 Mar;296(3):898-904. J Pharmacol Exp Ther. 2001. PMID: 11181922

2

Cross-species comparison of in vivo PK/PD relationships for second-generation antisense oligonucleotides targeting apolipoprotein B-100.

Yu RZ, Lemonidis KM, Graham MJ, Matson JE, Crooke RM, Tribble DL, Wedel MK, Levin AA, Geary RS. Yu RZ, et al. Biochem Pharmacol. 2009 Mar 1;77(5):910-9. doi: 10.1016/j.bcp.2008.11.005. Epub 2008 Nov 14. Biochem Pharmacol. 2009. PMID: 19056355

3

Pharmacokinetics and pharmacodynamics of an antisense phosphorothioate oligonucleotide targeting Fas mRNA in mice.

Yu RZ, Zhang H, Geary RS, Graham M, Masarjian L, Lemonidis K, Crooke R, Dean NM, Levin AA. Yu RZ, et al. Among authors: crooke r. J Pharmacol Exp Ther. 2001 Feb;296(2):388-95. J Pharmacol Exp Ther. 2001. PMID: 11160622

4

Antisense drug discovery and development technology considered in a pharmacological context.

Crooke ST, Liang XH, Crooke RM, Baker BF, Geary RS. Crooke ST, et al. Among authors: crooke rm. Biochem Pharmacol. 2021 Jul;189:114196. doi: 10.1016/j.bcp.2020.114196. Epub 2020 Aug 13. Biochem Pharmacol. 2021. PMID: 32800852 Review.

5

In vitro pharmacokinetics of phosphorothioate antisense oligonucleotides.

Crooke RM, Graham MJ, Cooke ME, Crooke ST. Crooke RM, et al. Among authors: crooke st. J Pharmacol Exp Ther. 1995 Oct;275(1):462-73. J Pharmacol Exp Ther. 1995. PMID: 7562586

6

Metabolism of antisense oligonucleotides in rat liver homogenates.

Crooke RM, Graham MJ, Martin MJ, Lemonidis KM, Wyrzykiewiecz T, Cummins LL. Crooke RM, et al. J Pharmacol Exp Ther. 2000 Jan;292(1):140-9. J Pharmacol Exp Ther. 2000. PMID: 10604941

7

In vivo distribution and metabolism of a phosphorothioate oligonucleotide within rat liver after intravenous administration.

Graham MJ, Crooke ST, Monteith DK, Cooper SR, Lemonidis KM, Stecker KK, Martin MJ, Crooke RM. Graham MJ, et al. Among authors: crooke st, crooke rm. J Pharmacol Exp Ther. 1998 Jul;286(1):447-58. J Pharmacol Exp Ther. 1998. PMID: 9655890

8

Antisense therapy targeting apolipoprotein(a): a randomised, double-blind, placebo-controlled phase 1 study.

Tsimikas S, Viney NJ, Hughes SG, Singleton W, Graham MJ, Baker BF, Burkey JL, Yang Q, Marcovina SM, Geary RS, Crooke RM, Witztum JL. Tsimikas S, et al. Lancet. 2015 Oct 10;386(10002):1472-83. doi: 10.1016/S0140-6736(15)61252-1. Epub 2015 Jul 22. Lancet. 2015. PMID: 26210642 Clinical Trial.

9

An oral antisense oligonucleotide for PCSK9 inhibition.

Gennemark P, Walter K, Clemmensen N, Rekić D, Nilsson CAM, Knöchel J, Hölttä M, Wernevik L, Rosengren B, Kakol-Palm D, Wang Y, Yu RZ, Geary RS, Riney SJ, Monia BP, Isaksson R, Jansson-Löfmark R, Rocha CSJ, Lindén D, Hurt-Camejo E, Crooke R, Tillman L, Rydén-Bergsten T, Carlsson B, Andersson U, Elebring M, Tivesten A, Davies N. Gennemark P, et al. Among authors: crooke r. Sci Transl Med. 2021 May 12;13(593):eabe9117. doi: 10.1126/scitranslmed.abe9117. Sci Transl Med. 2021. PMID: 33980578

10

Cardiovascular and Metabolic Effects of ANGPTL3 Antisense Oligonucleotides.

Graham MJ, Lee RG, Brandt TA, Tai LJ, Fu W, Peralta R, Yu R, Hurh E, Paz E, McEvoy BW, Baker BF, Pham NC, Digenio A, Hughes SG, Geary RS, Witztum JL, Crooke RM, Tsimikas S. Graham MJ, et al. Among authors: crooke rm. N Engl J Med. 2017 Jul 20;377(3):222-232. doi: 10.1056/NEJMoa1701329. Epub 2017 May 24. N Engl J Med. 2017. PMID: 28538111 Free article. Clinical Trial.

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