Garcia-Echeverria C - Search Results

1

An intrahelical salt bridge within the trigger site stabilizes the GCN4 leucine zipper.

Kammerer RA, Jaravine VA, Frank S, Schulthess T, Landwehr R, Lustig A, Garcia-Echeverria C, Alexandrescu AT, Engel J, Steinmetz MO. Kammerer RA, et al. J Biol Chem. 2001 Apr 27;276(17):13685-8. doi: 10.1074/jbc.M010492200. Epub 2000 Dec 27. J Biol Chem. 2001. PMID: 11134036 Free article.

2

Phosphorylation disrupts the central helix in Op18/stathmin and suppresses binding to tubulin.

Steinmetz MO, Jahnke W, Towbin H, García-Echeverría C, Voshol H, Müller D, van Oostrum J. Steinmetz MO, et al. EMBO Rep. 2001 Jun;2(6):505-10. doi: 10.1093/embo-reports/kve105. EMBO Rep. 2001. PMID: 11415983 Free PMC article.

3

Exploring amyloid formation by a de novo design.

Kammerer RA, Kostrewa D, Zurdo J, Detken A, García-Echeverría C, Green JD, Müller SA, Meier BH, Winkler FK, Dobson CM, Steinmetz MO. Kammerer RA, et al. Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4435-40. doi: 10.1073/pnas.0306786101. Epub 2004 Feb 26. Proc Natl Acad Sci U S A. 2004. PMID: 15070736 Free PMC article.

4

Antennapedia and HIV transactivator of transcription (TAT) "protein transduction domains" promote endocytosis of high molecular weight cargo upon binding to cell surface glycosaminoglycans.

Console S, Marty C, García-Echeverría C, Schwendener R, Ballmer-Hofer K. Console S, et al. J Biol Chem. 2003 Sep 12;278(37):35109-14. doi: 10.1074/jbc.M301726200. Epub 2003 Jun 30. J Biol Chem. 2003. PMID: 12837762 Free article.

5

Potent antagonists of the SH2 domain of Grb2: optimization of the X+1 position of 3-amino-Z-Tyr(PO3H2)-X+1-Asn-NH2.

García-Echeverría C, Furet P, Gay B, Fretz H, Rahuel J, Schoepfer J, Caravatti G. García-Echeverría C, et al. J Med Chem. 1998 May 21;41(11):1741-4. doi: 10.1021/jm970856n. J Med Chem. 1998. PMID: 9599224 No abstract available.

6

Entry into a new class of potent proteasome inhibitors having high antiproliferative activity by structure-based design.

Furet P, Imbach P, Noorani M, Koeppler J, Laumen K, Lang M, Guagnano V, Fuerst P, Roesel J, Zimmermann J, García-Echeverría C. Furet P, et al. J Med Chem. 2004 Sep 23;47(20):4810-3. doi: 10.1021/jm049660v. J Med Chem. 2004. PMID: 15369383 Free article.

7

Discovery of potent antagonists of the interaction between human double minute 2 and tumor suppressor p53.

García-Echeverría C, Chène P, Blommers MJ, Furet P. García-Echeverría C, et al. J Med Chem. 2000 Aug 24;43(17):3205-8. doi: 10.1021/jm990966p. J Med Chem. 2000. PMID: 10966738 No abstract available.

8

Mapping the X(+1) binding site of the Grb2-SH2 domain with alpha,alpha-disubstituted cyclic alpha-amino acids.

García-Echeverría C, Gay B, Rahuel J, Furet P. García-Echeverría C, et al. Bioorg Med Chem Lett. 1999 Oct 18;9(20):2915-20. doi: 10.1016/s0960-894x(99)00501-6. Bioorg Med Chem Lett. 1999. PMID: 10571147

9

A new Antennapedia-derived vector for intracellular delivery of exogenous compounds.

García-Echeverría C, Jiang L, Ramsey TM, Sharma SK, Chen YP. García-Echeverría C, et al. Bioorg Med Chem Lett. 2001 Jun 4;11(11):1363-6. doi: 10.1016/s0960-894x(01)00208-6. Bioorg Med Chem Lett. 2001. PMID: 11378355

10

Coupling of the antennapedia third helix to a potent antagonist of the p53/hdm2 protein-protein interaction.

García-Echeverría C, Furet P, Chène P. García-Echeverría C, et al. Bioorg Med Chem Lett. 2001 Aug 20;11(16):2161-4. doi: 10.1016/s0960-894x(01)00394-8. Bioorg Med Chem Lett. 2001. PMID: 11514160

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