Lobb R - Search Results

1

The Src kinase p56(lck) up-regulates VLA-4 integrin affinity. Implications for rapid spontaneous and chemokine-triggered T cell adhesion to VCAM-1 and fibronectin.

Feigelson SW, Grabovsky V, Winter E, Chen LL, Pepinsky RB, Yednock T, Yablonski D, Lobb R, Alon R. Feigelson SW, et al. Among authors: lobb r. J Biol Chem. 2001 Apr 27;276(17):13891-901. doi: 10.1074/jbc.M004939200. Epub 2000 Dec 1. J Biol Chem. 2001. PMID: 11102438 Free article.

2

High affinity very late antigen-4 subsets expressed on T cells are mandatory for spontaneous adhesion strengthening but not for rolling on VCAM-1 in shear flow.

Chen C, Mobley JL, Dwir O, Shimron F, Grabovsky V, Lobb RR, Shimizu Y, Alon R. Chen C, et al. Among authors: lobb rr. J Immunol. 1999 Jan 15;162(2):1084-95. J Immunol. 1999. PMID: 9916737

3

Multiple activation states of integrin alpha4beta1 detected through their different affinities for a small molecule ligand.

Chen LL, Whitty A, Lobb RR, Adams SP, Pepinsky RB. Chen LL, et al. Among authors: lobb rr. J Biol Chem. 1999 May 7;274(19):13167-75. doi: 10.1074/jbc.274.19.13167. J Biol Chem. 1999. PMID: 10224072 Free article.

4

Subsecond induction of alpha4 integrin clustering by immobilized chemokines stimulates leukocyte tethering and rolling on endothelial vascular cell adhesion molecule 1 under flow conditions.

Grabovsky V, Feigelson S, Chen C, Bleijs DA, Peled A, Cinamon G, Baleux F, Arenzana-Seisdedos F, Lapidot T, van Kooyk Y, Lobb RR, Alon R. Grabovsky V, et al. Among authors: lobb rr. J Exp Med. 2000 Aug 21;192(4):495-506. doi: 10.1084/jem.192.4.495. J Exp Med. 2000. PMID: 10952719 Free PMC article.

5

Evidence that ligand and metal ion binding to integrin alpha 4beta 1 are regulated through a coupled equilibrium.

Chen LL, Whitty A, Scott D, Lee WC, Cornebise M, Adams SP, Petter RC, Lobb RR, Pepinsky RB. Chen LL, et al. Among authors: lobb rr. J Biol Chem. 2001 Sep 28;276(39):36520-9. doi: 10.1074/jbc.M106216200. Epub 2001 Jul 25. J Biol Chem. 2001. PMID: 11473127 Free article.

6

Selective, tight-binding inhibitors of integrin alpha4beta1 that inhibit allergic airway responses.

Lin Kc, Ateeq HS, Hsiung SH, Chong LT, Zimmerman CN, Castro A, Lee WC, Hammond CE, Kalkunte S, Chen LL, Pepinsky RB, Leone DR, Sprague AG, Abraham WM, Gill A, Lobb RR, Adams SP. Lin Kc, et al. Among authors: lobb rr. J Med Chem. 1999 Mar 11;42(5):920-34. doi: 10.1021/jm980673g. J Med Chem. 1999. PMID: 10072689

7

Blockade of signaling via the very late antigen (VLA-4) and its counterligand vascular cell adhesion molecule-1 (VCAM-1) causes increased T cell apoptosis in experimental autoimmune neuritis.

Leussink VI, Zettl UK, Jander S, Pepinsky RB, Lobb RR, Stoll G, Toyka KV, Gold R. Leussink VI, et al. Among authors: lobb rr. Acta Neuropathol. 2002 Feb;103(2):131-6. doi: 10.1007/s004010100444. Epub 2001 Oct 31. Acta Neuropathol. 2002. PMID: 11810178

8

Identification of ligand binding sites on integrin alpha4beta1 through chemical cross-linking.

Chen LL, Lobb RR, Cuervo JH, Lin Kc, Adams SP, Pepinsky RB. Chen LL, et al. Among authors: lobb rr. Biochemistry. 1998 Jun 16;37(24):8743-53. doi: 10.1021/bi980311a. Biochemistry. 1998. PMID: 9628736

9

The role of the very late antigen-4 and its counterligand vascular cell adhesion molecule-1 in the pathogenesis of experimental autoimmune neuritis of the Lewis rat.

Enders U, Lobb R, Pepinsky RB, Hartung HP, Toyka KV, Gold R. Enders U, et al. Among authors: lobb r. Brain. 1998 Jul;121 ( Pt 7):1257-66. doi: 10.1093/brain/121.7.1257. Brain. 1998. PMID: 9679778

10

A direct binding assay for the vascular cell adhesion molecule-1 (VCAM1) interaction with alpha 4 integrins.

Lobb RR, Antognetti G, Pepinsky RB, Burkly LC, Leone DR, Whitty A. Lobb RR, et al. Cell Adhes Commun. 1995 Dec;3(5):385-97. doi: 10.3109/15419069509081293. Cell Adhes Commun. 1995. PMID: 8640376

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