Thurkauf A - Search Results

1

trans-1-[(2-Phenylcyclopropyl)methyl]-4-arylpiperazines: mixed dopamine D(2)/D(4) receptor antagonists as potential antipsychotic agents.

Zhang X, Hodgetts K, Rachwal S, Zhao H, Wasley JW, Craven K, Brodbeck R, Kieltyka A, Hoffman D, Bacolod MD, Girard B, Tran J, Thurkauf A. Zhang X, et al. Among authors: thurkauf a. J Med Chem. 2000 Oct 19;43(21):3923-32. doi: 10.1021/jm990562x. J Med Chem. 2000. PMID: 11052797

2

Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 1: identification and structure-activity relationships.

Zhao H, Thurkauf A, He X, Hodgetts K, Zhang X, Rachwal S, Kover RX, Hutchison A, Peterson J, Kieltyka A, Brodbeck R, Primus R, Wasley JW. Zhao H, et al. Among authors: thurkauf a. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3105-9. doi: 10.1016/s0960-894x(02)00655-8. Bioorg Med Chem Lett. 2002. PMID: 12372512

3

Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 2: asymmetric synthesis and biological evaluation.

Zhao H, He X, Thurkauf A, Hoffman D, Kieltyka A, Brodbeck R, Primus R, Wasley JW. Zhao H, et al. Among authors: thurkauf a. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3111-5. doi: 10.1016/s0960-894x(02)00656-x. Bioorg Med Chem Lett. 2002. PMID: 12372513

4

Design, synthesis, and discovery of 5-piperazinyl-1,2,6,7-tetrahydro-5H-azepino[3,2,1-hi]indol-4-one derivatives: a novel series of mixed dopamine D2/D4 receptor antagonist.

Zhao H, Zhang X, Hodgetts K, Thurkauf A, Hammer J, Chandrasekhar J, Kieltyka A, Brodbeck R, Rachwal S, Primus R, Manly C. Zhao H, et al. Among authors: thurkauf a. Bioorg Med Chem Lett. 2003 Feb 24;13(4):701-4. doi: 10.1016/s0960-894x(02)01056-9. Bioorg Med Chem Lett. 2003. PMID: 12639562

5

1H-Pyrazolo-[3,4-c]cyclophepta[1,2-c]thiophenes: a unique structural class of dopamine D4 selective ligands.

Thurkauf A, Chen X, Zhang S, Gao Y, Kieltyka A, Wasley JW, Brodbeck R, Greenlee W, Ganguly A, Zhao H. Thurkauf A, et al. Bioorg Med Chem Lett. 2003 Sep 1;13(17):2921-4. doi: 10.1016/s0960-894x(03)00587-0. Bioorg Med Chem Lett. 2003. PMID: 14611858

6

1-Phenyl-3-(aminomethyl)pyrroles as potential antipsychotic agents. Synthesis and dopamine receptor binding.

Thurkauf A, Yuan J, Chen X, Wasley JW, Meade R, Woodruff KH, Huston K, Ross PC. Thurkauf A, et al. J Med Chem. 1995 Dec 8;38(25):4950-2. doi: 10.1021/jm00025a013. J Med Chem. 1995. PMID: 8523409

7

2-Phenyl-4(5)-[[4-(pyrimidin-2-yl)piperazin-1-yl]methyl]imidazole. A highly selective antagonist at cloned human D4 receptors.

Thurkauf A, Yuan J, Chen X, He XS, Wasley JW, Hutchison A, Woodruff KH, Meade R, Hoffman DC, Donovan H, Jones-Hertzog DK. Thurkauf A, et al. J Med Chem. 1997 Jan 3;40(1):1-3. doi: 10.1021/jm960637m. J Med Chem. 1997. PMID: 9016321 No abstract available.

8

NGB 2904 and NGB 2849: two highly selective dopamine D3 receptor antagonists.

Yuan J, Chen X, Brodbeck R, Primus R, Braun J, Wasley JW, Thurkauf A. Yuan J, et al. Among authors: thurkauf a. Bioorg Med Chem Lett. 1998 Oct 6;8(19):2715-8. doi: 10.1016/s0960-894x(98)00469-7. Bioorg Med Chem Lett. 1998. PMID: 9873609

9

Design, synthesis, and discovery of 3-piperazinyl-3,4-dihydro-2(1H)-quinolinone derivatives: a novel series of mixed dopamine D2/D4 receptor antagonists.

Zhao H, Thurkauf A, Braun J, Brodbeck R, Kieltyka A. Zhao H, et al. Among authors: thurkauf a. Bioorg Med Chem Lett. 2000 Sep 18;10(18):2119-22. doi: 10.1016/s0960-894x(00)00421-2. Bioorg Med Chem Lett. 2000. PMID: 10999484

10

6-(4-Benzylpiperazin-1-yl)benzodioxanes as selective ligands at cloned primate dopamine D(4) receptors.

Hodgetts KJ, Kieltyka A, Brodbeck R, Tran JN, Wasley JW, Thurkauf A. Hodgetts KJ, et al. Among authors: thurkauf a. Bioorg Med Chem. 2001 Dec;9(12):3207-13. doi: 10.1016/s0968-0896(01)00226-7. Bioorg Med Chem. 2001. PMID: 11711296

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