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HER-2/neu-derived peptide 884-899 is expressed by human breast, colorectal and pancreatic adenocarcinomas and is recognized by in-vitro-induced specific CD4(+) T cell clones.
Perez SA, Sotiropoulou PA, Sotiriadou NN, Mamalaki A, Gritzapis AD, Echner H, Voelter W, Pawelec G, Papamichail M, Baxevanis CN. Perez SA, et al. Among authors: voelter w. Cancer Immunol Immunother. 2002 Jan;50(11):615-24. doi: 10.1007/s002620100225. Epub 2001 Nov 23. Cancer Immunol Immunother. 2002. PMID: 11807625 Free PMC article.
The immunologically active site of prothymosin alpha is located at the carboxy-terminus of the polypeptide. Evaluation of its in vitro effects in cancer patients.
Skopeliti M, Voutsas IF, Klimentzou P, Tsiatas ML, Beck A, Bamias A, Moraki M, Livaniou E, Neagu M, Voelter W, Tsitsilonis OE. Skopeliti M, et al. Among authors: voelter w. Cancer Immunol Immunother. 2006 Oct;55(10):1247-57. doi: 10.1007/s00262-005-0108-4. Epub 2006 Feb 2. Cancer Immunol Immunother. 2006. PMID: 16453152 Free PMC article.
Prothymosin Alpha: An Alarmin and More..
Samara P, Karachaliou CE, Ioannou K, Papaioannou NE, Voutsas IF, Zikos C, Pirmettis I, Papadopoulos M, Kalbacher H, Livaniou E, Tsitsilonis OE, Voelter W. Samara P, et al. Among authors: voelter w. Curr Med Chem. 2017;24(17):1747-1760. doi: 10.2174/0929867324666170518110033. Curr Med Chem. 2017. PMID: 28521686 Review.
The prognostic value of alpha-thymosins in breast cancer.
Tsitsilonis OE, Bekris E, Voutsas IF, Baxevanis CN, Markopoulos C, Papadopoulou SA, Kontzoglou K, Stoeva S, Gogas J, Voelter W, Papamichail M. Tsitsilonis OE, et al. Among authors: voelter w. Anticancer Res. 1998 May-Jun;18(3A):1501-8. Anticancer Res. 1998. PMID: 9673361
Prothymosin alpha immunoactive carboxyl-terminal peptide TKKQKTDEDD stimulates lymphocyte reactions, induces dendritic cell maturation and adopts a beta-sheet conformation in a sequence-specific manner.
Skopeliti M, Iconomidou VA, Derhovanessian E, Pawelec G, Voelter W, Kalbacher H, Hamodrakas SJ, Tsitsilonis OE. Skopeliti M, et al. Among authors: voelter w. Mol Immunol. 2009 Feb;46(5):784-92. doi: 10.1016/j.molimm.2008.09.014. Epub 2008 Oct 30. Mol Immunol. 2009. PMID: 18976813
350 results