Pearson PG - Search Results

1

Metabolites of caspofungin acetate, a potent antifungal agent, in human plasma and urine.

Balani SK, Xu X, Arison BH, Silva MV, Gries A, DeLuna FA, Cui D, Kari PH, Ly T, Hop CE, Singh R, Wallace MA, Dean DC, Lin JH, Pearson PG, Baillie TA. Balani SK, et al. Among authors: pearson pg. Drug Metab Dispos. 2000 Nov;28(11):1274-8. Drug Metab Dispos. 2000. PMID: 11038152

2

Glucuronidation of statins in animals and humans: a novel mechanism of statin lactonization.

Prueksaritanont T, Subramanian R, Fang X, Ma B, Qiu Y, Lin JH, Pearson PG, Baillie TA. Prueksaritanont T, et al. Among authors: pearson pg. Drug Metab Dispos. 2002 May;30(5):505-12. doi: 10.1124/dmd.30.5.505. Drug Metab Dispos. 2002. PMID: 11950779

3

Disposition of caspofungin, a novel antifungal agent, in mice, rats, rabbits, and monkeys.

Sandhu P, Xu X, Bondiskey PJ, Balani SK, Morris ML, Tang YS, Miller AR, Pearson PG. Sandhu P, et al. Among authors: pearson pg. Antimicrob Agents Chemother. 2004 Apr;48(4):1272-80. doi: 10.1128/AAC.48.4.1272-1280.2004. Antimicrob Agents Chemother. 2004. PMID: 15047529 Free PMC article.

4

Evaluation of microdosing strategies for studies in preclinical drug development: demonstration of linear pharmacokinetics in dogs of a nucleoside analog over a 50-fold dose range.

Sandhu P, Vogel JS, Rose MJ, Ubick EA, Brunner JE, Wallace MA, Adelsberger JK, Baker MP, Henderson PT, Pearson PG, Baillie TA. Sandhu P, et al. Among authors: pearson pg. Drug Metab Dispos. 2004 Nov;32(11):1254-9. doi: 10.1124/dmd.104.000422. Epub 2004 Jul 30. Drug Metab Dispos. 2004. PMID: 15286054

5

Hepatic uptake of the novel antifungal agent caspofungin.

Sandhu P, Lee W, Xu X, Leake BF, Yamazaki M, Stone JA, Lin JH, Pearson PG, Kim RB. Sandhu P, et al. Among authors: pearson pg. Drug Metab Dispos. 2005 May;33(5):676-82. doi: 10.1124/dmd.104.003244. Epub 2005 Feb 16. Drug Metab Dispos. 2005. PMID: 15716364

6

Disposition of caspofungin: role of distribution in determining pharmacokinetics in plasma.

Stone JA, Xu X, Winchell GA, Deutsch PJ, Pearson PG, Migoya EM, Mistry GC, Xi L, Miller A, Sandhu P, Singh R, deLuna F, Dilzer SC, Lasseter KC. Stone JA, et al. Among authors: pearson pg. Antimicrob Agents Chemother. 2004 Mar;48(3):815-23. doi: 10.1128/AAC.48.3.815-823.2004. Antimicrob Agents Chemother. 2004. PMID: 14982770 Free PMC article. Clinical Trial.

7

Metabolic activation of a pyrazinone-containing thrombin inhibitor. Evidence for novel biotransformation involving pyrazinone ring oxidation, rearrangement, and covalent binding to proteins.

Singh R, Silva Elipe MV, Pearson PG, Arison BH, Wong BK, White R, Yu X, Burgey CS, Lin JH, Baillie TA. Singh R, et al. Among authors: pearson pg. Chem Res Toxicol. 2003 Feb;16(2):198-207. doi: 10.1021/tx025635l. Chem Res Toxicol. 2003. PMID: 12588191

8

Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission.

Kassahun K, Pearson PG, Tang W, McIntosh I, Leung K, Elmore C, Dean D, Wang R, Doss G, Baillie TA. Kassahun K, et al. Among authors: pearson pg. Chem Res Toxicol. 2001 Jan;14(1):62-70. doi: 10.1021/tx000180q. Chem Res Toxicol. 2001. PMID: 11170509

9

Enzyme kinetics of cytochrome P450-mediated reactions.

Shou M, Lin Y, Lu P, Tang C, Mei Q, Cui D, Tang W, Ngui JS, Lin CC, Singh R, Wong BK, Yergey JA, Lin JH, Pearson PG, Baillie TA, Rodrigues AD, Rushmore TH. Shou M, et al. Among authors: pearson pg. Curr Drug Metab. 2001 Mar;2(1):17-36. doi: 10.2174/1389200013338784. Curr Drug Metab. 2001. PMID: 11465149 Review.

10

Mechanistic studies on metabolic interactions between gemfibrozil and statins.

Prueksaritanont T, Zhao JJ, Ma B, Roadcap BA, Tang C, Qiu Y, Liu L, Lin JH, Pearson PG, Baillie TA. Prueksaritanont T, et al. Among authors: pearson pg. J Pharmacol Exp Ther. 2002 Jun;301(3):1042-51. doi: 10.1124/jpet.301.3.1042. J Pharmacol Exp Ther. 2002. PMID: 12023536

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