Nicklaus MC - Search Results

1

Interactions of conformationally biased north and south 2'-fluoro-2', 3'-dideoxynucleoside 5'-triphosphates with the active site of HIV-1 reverse transcriptase.

Mu L, Sarafianos SG, Nicklaus MC, Russ P, Siddiqui MA, Ford H Jr, Mitsuya H, Le R, Kodama E, Meier C, Knispel T, Anderson L, Barchi JJ Jr, Marquez VE. Mu L, et al. Among authors: nicklaus mc. Biochemistry. 2000 Sep 19;39(37):11205-15. doi: 10.1021/bi001090n. Biochemistry. 2000. PMID: 10985766

2

Effects of tyrphostins, protein kinase inhibitors, on human immunodeficiency virus type 1 integrase.

Mazumder A, Gazit A, Levitzki A, Nicklaus M, Yung J, Kohlhagen G, Pommier Y. Mazumder A, et al. Biochemistry. 1995 Nov 21;34(46):15111-22. doi: 10.1021/bi00046a018. Biochemistry. 1995. PMID: 7578125

3

Conformationally locked nucleoside analogues. Synthesis of dideoxycarbocyclic nucleoside analogues structurally related to neplanocin C.

Rodriguez JB, Marquez VE, Nicklaus MC, Mitsuya H, Barchi JJ Jr. Rodriguez JB, et al. Among authors: nicklaus mc. J Med Chem. 1994 Sep 30;37(20):3389-99. doi: 10.1021/jm00046a024. J Med Chem. 1994. PMID: 7932567

4

Protein kinase C. Modeling of the binding site and prediction of binding constants.

Wang S, Milne GW, Nicklaus MC, Marquez VE, Lee J, Blumberg PM. Wang S, et al. Among authors: nicklaus mc. J Med Chem. 1994 Apr 29;37(9):1326-38. doi: 10.1021/jm00035a013. J Med Chem. 1994. PMID: 8176711

5

Conformationally restricted nucleosides. The reaction of adenosine deaminase with substrates built on a bicyclo[3.1.0]hexane template.

Marquez VE, Russ P, Alonso R, Siddiqui MA, Shin KJ, George C, Nicklaus MC, Dai F, Ford H Jr. Marquez VE, et al. Among authors: nicklaus mc. Nucleosides Nucleotides. 1999 Apr-May;18(4-5):521-30. doi: 10.1080/15257779908041487. Nucleosides Nucleotides. 1999. PMID: 10432643

6

Adenosine deaminase prefers a distinct sugar ring conformation for binding and catalysis: kinetic and structural studies.

Ford H Jr, Dai F, Mu L, Siddiqui MA, Nicklaus MC, Anderson L, Marquez VE, Barchi JJ Jr. Ford H Jr, et al. Among authors: nicklaus mc. Biochemistry. 2000 Mar 14;39(10):2581-92. doi: 10.1021/bi992112c. Biochemistry. 2000. PMID: 10704207

7

Identification of HIV-1 integrase inhibitors via three-dimensional database searching using ASV and HIV-1 integrases as targets.

Chen IJ, Neamati N, Nicklaus MC, Orr A, Anderson L, Barchi JJ Jr, Kelley JA, Pommier Y, MacKerell AD Jr. Chen IJ, et al. Among authors: nicklaus mc. Bioorg Med Chem. 2000 Oct;8(10):2385-98. doi: 10.1016/s0968-0896(00)00180-2. Bioorg Med Chem. 2000. PMID: 11058033

8

An optimized protein kinase C activating diacylglycerol combining high binding affinity (Ki) with reduced lipophilicity (log P).

Nacro K, Sigano DM, Yan S, Nicklaus MC, Pearce LL, Lewin NE, Garfield SH, Blumberg PM, Marquez VE. Nacro K, et al. Among authors: nicklaus mc. J Med Chem. 2001 Jun 7;44(12):1892-904. doi: 10.1021/jm010052e. J Med Chem. 2001. PMID: 11384235

9

Inhibition of (cytosine C5)-methyltransferase by oligonucleotides containing flexible (cyclopentane) and conformationally constrained (bicyclo[3.1.0]hexane) abasic sites.

Marquez VE, Wang P, Nicklaus MC, Maier M, Manoharan M, Christman JK, Banavali NK, Mackerell AD Jr. Marquez VE, et al. Among authors: nicklaus mc. Nucleosides Nucleotides Nucleic Acids. 2001 Apr-Jul;20(4-7):451-9. doi: 10.1081/NCN-100002319. Nucleosides Nucleotides Nucleic Acids. 2001. PMID: 11563060 Review.

10

Conformationally constrained analogues of diacylglycerol. 18. The incorporation of a hydroxamate moiety into diacylglycerol-lactones reduces lipophilicity and helps discriminate between sn-1 and sn-2 binding modes to protein kinase C (PK-C). Implications for isozyme specificity.

Lee J, Han KC, Kang JH, Pearce LL, Lewin NE, Yan S, Benzaria S, Nicklaus MC, Blumberg PM, Marquez VE. Lee J, et al. Among authors: nicklaus mc. J Med Chem. 2001 Dec 6;44(25):4309-12. doi: 10.1021/jm0103965. J Med Chem. 2001. PMID: 11728178

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