Ye F - Search Results

1

4-Anilino-6,7-dialkoxyquinoline-3-carbonitrile inhibitors of epidermal growth factor receptor kinase and their bioisosteric relationship to the 4-anilino-6,7-dialkoxyquinazoline inhibitors.

Wissner A, Berger DM, Boschelli DH, Floyd MB Jr, Greenberger LM, Gruber BC, Johnson BD, Mamuya N, Nilakantan R, Reich MF, Shen R, Tsou HR, Upeslacis E, Wang YF, Wu B, Ye F, Zhang N. Wissner A, et al. Among authors: ye f. J Med Chem. 2000 Aug 24;43(17):3244-56. doi: 10.1021/jm000206a. J Med Chem. 2000. PMID: 10966743

2

Inhibitors of src tyrosine kinase: the preparation and structure-activity relationship of 4-anilino-3-cyanoquinolines and 4-anilinoquinazolines.

Wang YD, Miller K, Boschelli DH, Ye F, Wu B, Floyd MB, Powell DW, Wissner A, Weber JM, Boschelli F. Wang YD, et al. Among authors: ye f. Bioorg Med Chem Lett. 2000 Nov 6;10(21):2477-80. doi: 10.1016/s0960-894x(00)00493-5. Bioorg Med Chem Lett. 2000. PMID: 11078204

3

Synthesis and Src kinase inhibitory activity of a series of 4-phenylamino-3-quinolinecarbonitriles.

Boschelli DH, Wang YD, Ye F, Wu B, Zhang N, Dutia M, Powell DW, Wissner A, Arndt K, Weber JM, Boschelli F. Boschelli DH, et al. Among authors: ye f. J Med Chem. 2001 Mar 1;44(5):822-33. doi: 10.1021/jm000420z. J Med Chem. 2001. PMID: 11262092

4

MEK (MAPKK) inhibitors. Part 2: structure-activity relationships of 4-anilino-3-cyano-6,7-dialkoxyquinolines.

Zhang N, Wu B, Eudy N, Wang Y, Ye F, Powell D, Wissner A, Feldberg LR, Kim SC, Mallon R, Kovacs ED, Toral-Barza L, Kohler CA. Zhang N, et al. Among authors: ye f. Bioorg Med Chem Lett. 2001 Jun 4;11(11):1407-10. doi: 10.1016/s0960-894x(01)00238-4. Bioorg Med Chem Lett. 2001. PMID: 11378365

5

6-Substituted-4-(3-bromophenylamino)quinazolines as putative irreversible inhibitors of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases with enhanced antitumor activity.

Tsou HR, Mamuya N, Johnson BD, Reich MF, Gruber BC, Ye F, Nilakantan R, Shen R, Discafani C, DeBlanc R, Davis R, Koehn FE, Greenberger LM, Wang YF, Wissner A. Tsou HR, et al. Among authors: ye f. J Med Chem. 2001 Aug 16;44(17):2719-34. doi: 10.1021/jm0005555. J Med Chem. 2001. PMID: 11495584

6

Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity.

Boschelli DH, Ye F, Wang YD, Dutia M, Johnson SL, Wu B, Miller K, Powell DW, Yaczko D, Young M, Tischler M, Arndt K, Discafani C, Etienne C, Gibbons J, Grod J, Lucas J, Weber JM, Boschelli F. Boschelli DH, et al. Among authors: ye f. J Med Chem. 2001 Nov 8;44(23):3965-77. doi: 10.1021/jm0102250. J Med Chem. 2001. PMID: 11689083

7

Inhibition of Src kinase activity by 4-anilino-7-thienyl-3-quinolinecarbonitriles.

Boschelli DH, Wang DY, Ye F, Yamashita A, Zhang N, Powell D, Weber J, Boschelli F. Boschelli DH, et al. Among authors: ye f. Bioorg Med Chem Lett. 2002 Aug 5;12(15):2011-4. doi: 10.1016/s0960-894x(02)00302-5. Bioorg Med Chem Lett. 2002. PMID: 12113830

8

Synthesis and structure-activity relationships of 6,7-disubstituted 4-anilinoquinoline-3-carbonitriles. The design of an orally active, irreversible inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor-2 (HER-2).

Wissner A, Overbeek E, Reich MF, Floyd MB, Johnson BD, Mamuya N, Rosfjord EC, Discafani C, Davis R, Shi X, Rabindran SK, Gruber BC, Ye F, Hallett WA, Nilakantan R, Shen R, Wang YF, Greenberger LM, Tsou HR. Wissner A, et al. Among authors: ye f. J Med Chem. 2003 Jan 2;46(1):49-63. doi: 10.1021/jm020241c. J Med Chem. 2003. PMID: 12502359

9

SKI-606, a 4-anilino-3-quinolinecarbonitrile dual inhibitor of Src and Abl kinases, is a potent antiproliferative agent against chronic myelogenous leukemia cells in culture and causes regression of K562 xenografts in nude mice.

Golas JM, Arndt K, Etienne C, Lucas J, Nardin D, Gibbons J, Frost P, Ye F, Boschelli DH, Boschelli F. Golas JM, et al. Among authors: ye f. Cancer Res. 2003 Jan 15;63(2):375-81. Cancer Res. 2003. PMID: 12543790

10

Investigation of the effect of varying the 4-anilino and 7-alkoxy groups of 3-quinolinecarbonitriles on the inhibition of Src kinase activity.

Boschelli DH, Ye F, Wu B, Wang YD, Barrios Sosa AC, Yaczko D, Powell D, Golas JM, Lucas J, Boschelli F. Boschelli DH, et al. Among authors: ye f. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3797-800. doi: 10.1016/j.bmcl.2003.07.001. Bioorg Med Chem Lett. 2003. PMID: 14552782

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