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Mice overexpressing human uncoupling protein-3 in skeletal muscle are hyperphagic and lean.
Clapham JC, Arch JR, Chapman H, Haynes A, Lister C, Moore GB, Piercy V, Carter SA, Lehner I, Smith SA, Beeley LJ, Godden RJ, Herrity N, Skehel M, Changani KK, Hockings PD, Reid DG, Squires SM, Hatcher J, Trail B, Latcham J, Rastan S, Harper AJ, Cadenas S, Buckingham JA, Brand MD, Abuin A. Clapham JC, et al. Among authors: chapman h. Nature. 2000 Jul 27;406(6794):415-8. doi: 10.1038/35019082. Nature. 2000. PMID: 10935638
Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for peroxisomal proliferator-activated receptor gamma.
Young PW, Buckle DR, Cantello BC, Chapman H, Clapham JC, Coyle PJ, Haigh D, Hindley RM, Holder JC, Kallender H, Latter AJ, Lawrie KW, Mossakowska D, Murphy GJ, Roxbee Cox L, Smith SA. Young PW, et al. Among authors: chapman h. J Pharmacol Exp Ther. 1998 Feb;284(2):751-9. J Pharmacol Exp Ther. 1998. PMID: 9454824
v- and t-SNARE protein expression in models of insulin resistance: normalization of glycemia by rosiglitazone treatment corrects overexpression of cellubrevin, vesicle-associated membrane protein-2, and syntaxin 4 in skeletal muscle of Zucker diabetic fatty rats.
Maier VH, Melvin DR, Lister CA, Chapman H, Gould GW, Murphy GJ. Maier VH, et al. Among authors: chapman h. Diabetes. 2000 Apr;49(4):618-25. doi: 10.2337/diabetes.49.4.618. Diabetes. 2000. PMID: 10871200
The contribution of classical (beta1/2-) and atypical beta-adrenoceptors to the stimulation of human white adipocyte lipolysis and right atrial appendage contraction by novel beta3-adrenoceptor agonists of differing selectivities.
Sennitt MV, Kaumann AJ, Molenaar P, Beeley LJ, Young PW, Kelly J, Chapman H, Henson SM, Berge JM, Dean DK, Kotecha NR, Morgan HK, Rami HK, Ward RW, Thompson M, Wilson S, Smith SA, Cawthorne MA, Stock MJ, Arch JR. Sennitt MV, et al. Among authors: chapman h. J Pharmacol Exp Ther. 1998 Jun;285(3):1084-95. J Pharmacol Exp Ther. 1998. PMID: 9618411
1,035 results