Shifman JM - Search Results

1

Computational design of an integrin I domain stabilized in the open high affinity conformation.

Shimaoka M, Shifman JM, Jing H, Takagi J, Mayo SL, Springer TA. Shimaoka M, et al. Among authors: shifman jm. Nat Struct Biol. 2000 Aug;7(8):674-8. doi: 10.1038/77978. Nat Struct Biol. 2000. PMID: 10932253

2

Modulating calmodulin binding specificity through computational protein design.

Shifman JM, Mayo SL. Shifman JM, et al. J Mol Biol. 2002 Oct 25;323(3):417-23. doi: 10.1016/s0022-2836(02)00881-1. J Mol Biol. 2002. PMID: 12381298

3

Exploring the origins of binding specificity through the computational redesign of calmodulin.

Shifman JM, Mayo SL. Shifman JM, et al. Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13274-9. doi: 10.1073/pnas.2234277100. Epub 2003 Nov 3. Proc Natl Acad Sci U S A. 2003. PMID: 14597710 Free PMC article.

4

Ca2+/calmodulin-dependent protein kinase II (CaMKII) is activated by calmodulin with two bound calciums.

Shifman JM, Choi MH, Mihalas S, Mayo SL, Kennedy MB. Shifman JM, et al. Proc Natl Acad Sci U S A. 2006 Sep 19;103(38):13968-73. doi: 10.1073/pnas.0606433103. Epub 2006 Sep 11. Proc Natl Acad Sci U S A. 2006. PMID: 16966599 Free PMC article.

5

Computational design of calmodulin mutants with up to 900-fold increase in binding specificity.

Yosef E, Politi R, Choi MH, Shifman JM. Yosef E, et al. Among authors: shifman jm. J Mol Biol. 2009 Feb 6;385(5):1470-80. doi: 10.1016/j.jmb.2008.09.053. Epub 2008 Sep 27. J Mol Biol. 2009. PMID: 18845160

6

Transfer-PCR (TPCR): a highway for DNA cloning and protein engineering.

Erijman A, Dantes A, Bernheim R, Shifman JM, Peleg Y. Erijman A, et al. Among authors: shifman jm. J Struct Biol. 2011 Aug;175(2):171-7. doi: 10.1016/j.jsb.2011.04.005. Epub 2011 Apr 15. J Struct Biol. 2011. PMID: 21515384

7

Alteration of the C-terminal ligand specificity of the erbin PDZ domain by allosteric mutational effects.

Murciano-Calles J, McLaughlin ME, Erijman A, Hooda Y, Chakravorty N, Martinez JC, Shifman JM, Sidhu SS. Murciano-Calles J, et al. Among authors: shifman jm. J Mol Biol. 2014 Oct 23;426(21):3500-8. doi: 10.1016/j.jmb.2014.05.003. Epub 2014 May 9. J Mol Biol. 2014. PMID: 24813123

8

What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf.

Filchtinski D, Sharabi O, Rüppel A, Vetter IR, Herrmann C, Shifman JM. Filchtinski D, et al. Among authors: shifman jm. J Mol Biol. 2010 Jun 11;399(3):422-35. doi: 10.1016/j.jmb.2010.03.046. Epub 2010 Mar 31. J Mol Biol. 2010. PMID: 20361980

9

Editorial overview: Engineering and design: New trends in designer proteins.

Shifman JM, Papo N. Shifman JM, et al. Curr Opin Struct Biol. 2017 Aug;45:iv-vi. doi: 10.1016/j.sbi.2017.03.001. Epub 2017 Mar 15. Curr Opin Struct Biol. 2017. PMID: 28314629 No abstract available.

10

Computational design and experimental optimization of protein binders with prospects for biomedical applications.

Bonadio A, Shifman JM. Bonadio A, et al. Among authors: shifman jm. Protein Eng Des Sel. 2021 Feb 15;34:gzab020. doi: 10.1093/protein/gzab020. Protein Eng Des Sel. 2021. PMID: 34436606 Free PMC article. Review.

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