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A molecular clone of simian-human immunodeficiency virus (DeltavpuSHIV(KU-1bMC33)) with a truncated, non-membrane-bound vpu results in rapid CD4(+) T cell loss and neuro-AIDS in pig-tailed macaques.
McCormick-Davis C, Dalton SB, Hout DR, Singh DK, Berman NE, Yong C, Pinson DM, Foresman L, Stephens EB. McCormick-Davis C, et al. Among authors: singh dk. Virology. 2000 Jun 20;272(1):112-26. doi: 10.1006/viro.2000.0333. Virology. 2000. PMID: 10873754 Free article.
Deletion of the vpu sequences prior to the env in a simian-human immunodeficiency virus results in enhanced Env precursor synthesis but is less pathogenic for pig-tailed macaques.
Stephens EB, McCormick C, Pacyniak E, Griffin D, Pinson DM, Sun F, Nothnick W, Wong SW, Gunderson R, Berman NE, Singh DK. Stephens EB, et al. Among authors: singh dk. Virology. 2002 Feb 15;293(2):252-61. doi: 10.1006/viro.2001.1244. Virology. 2002. PMID: 11886245 Free article.
The presence of the casein kinase II phosphorylation sites of Vpu enhances the CD4(+) T cell loss caused by the simian-human immunodeficiency virus SHIV(KU-lbMC33) in pig-tailed macaques.
Singh DK, Griffin DM, Pacyniak E, Jackson M, Werle MJ, Wisdom B, Sun F, Hout DR, Pinson DM, Gunderson RS, Powers MF, Wong SW, Stephens EB. Singh DK, et al. Virology. 2003 Sep 1;313(2):435-51. doi: 10.1016/s0042-6822(03)00339-8. Virology. 2003. PMID: 12954211 Free article.
A cell-free stock of simian-human immunodeficiency virus that causes AIDS in pig-tailed macaques has a limited number of amino acid substitutions in both SIVmac and HIV-1 regions of the genome and has offered cytotropism.
Stephens EB, Mukherjee S, Sahni M, Zhuge W, Raghavan R, Singh DK, Leung K, Atkinson B, Li Z, Joag SV, Liu ZQ, Narayan O. Stephens EB, et al. Among authors: singh dk. Virology. 1997 May 12;231(2):313-21. doi: 10.1006/viro.1997.8534. Virology. 1997. PMID: 9168893 Free article.
Comparison of Vpu sequences from diverse geographical isolates of HIV type 1 identifies the presence of highly variable domains, additional invariant amino acids, and a signature sequence motif common to subtype C isolates.
McCormick-Davis C, Dalton SB, Singh DK, Stephens EB. McCormick-Davis C, et al. Among authors: singh dk. AIDS Res Hum Retroviruses. 2000 Jul 20;16(11):1089-95. doi: 10.1089/08892220050075363. AIDS Res Hum Retroviruses. 2000. PMID: 10933625
A simian human immunodeficiency virus with a nonfunctional Vpu (deltavpuSHIV(KU-1bMC33)) isolated from a macaque with neuroAIDS has selected for mutations in env and nef that contributed to its pathogenic phenotype.
Singh DK, McCormick C, Pacyniak E, Lawrence K, Dalton SB, Pinson DM, Sun F, Berman NE, Calvert M, Gunderson RS, Wong SW, Stephens EB. Singh DK, et al. Virology. 2001 Mar 30;282(1):123-40. doi: 10.1006/viro.2000.0821. Virology. 2001. PMID: 11259196 Free article.
1,003 results