Hedrick MP - Search Results

1

Synthesis and evaluation of 1,2,8, 8a-Tetrahydrocyclopropa[c]pyrrolo[3,2-e]indol-4(5H)-one, the parent alkylation subunit of CC-1065 and the duocarmycins: impact of the alkylation subunit substituents and its implications for DNA alkylation catalysis.

Boger DL, Santillán A Jr, Searcey M, Brunette SR, Wolkenberg SE, Hedrick MP, Jin Q. Boger DL, et al. Among authors: hedrick mp. J Org Chem. 2000 Jun 30;65(13):4101-11. doi: 10.1021/jo000297j. J Org Chem. 2000. PMID: 10866627

2

Establishment of substituent effects in the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.

Parrish JP, Kastrinsky DB, Stauffer F, Hedrick MP, Hwang I, Boger DL. Parrish JP, et al. Among authors: hedrick mp. Bioorg Med Chem. 2003 Aug 15;11(17):3815-38. doi: 10.1016/s0968-0896(03)00194-9. Bioorg Med Chem. 2003. PMID: 12901927

3

Total synthesis of ningalin B utilizing a heterocyclic azadiene Diels-Alder reaction and discovery of a new class of potent multidrug resistant (MDR) reversal agents.

Boger DL, Soenen DR, Boyce CW, Hedrick MP, Jin Q. Boger DL, et al. Among authors: hedrick mp. J Org Chem. 2000 Apr 21;65(8):2479-83. doi: 10.1021/jo9916535. J Org Chem. 2000. PMID: 10789460

4

Synthesis, chemical properties, and biological evaluation of CC-1065 and duocarmycin analogues incorporating the 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa.

Boger DL, Hughes TV, Hedrick MP. Boger DL, et al. Among authors: hedrick mp. J Org Chem. 2001 Apr 6;66(7):2207-16. doi: 10.1021/jo001772g. J Org Chem. 2001. PMID: 11281757

5

Substituent effects within the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.

Boger DL, Stauffer F, Hedrick MP. Boger DL, et al. Among authors: hedrick mp. Bioorg Med Chem Lett. 2001 Aug 6;11(15):2021-4. doi: 10.1016/s0960-894x(01)00372-9. Bioorg Med Chem Lett. 2001. PMID: 11454471

6

Parallel synthesis and evaluation of 132 (+)-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogues of CC-1065 and the duocarmycins defining the contribution of the DNA-binding domain.

Boger DL, Schmitt HW, Fink BE, Hedrick MP. Boger DL, et al. Among authors: hedrick mp. J Org Chem. 2001 Oct 5;66(20):6654-61. doi: 10.1021/jo010454u. J Org Chem. 2001. PMID: 11578217

7

A new class of highly cytotoxic diketopiperazines.

Boger DL, Fink BE, Hedrick MP. Boger DL, et al. Among authors: hedrick mp. Bioorg Med Chem Lett. 2000 May 15;10(10):1019-20. doi: 10.1016/s0960-894x(00)00152-9. Bioorg Med Chem Lett. 2000. PMID: 10843206

8

Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.

Boger DL, Marsilje TH, Castro RA, Hedrick MP, Jin Q, Baker SJ, Shim JH, Benkovic SJ. Boger DL, et al. Among authors: hedrick mp. Bioorg Med Chem Lett. 2000 Jul 3;10(13):1471-5. doi: 10.1016/s0960-894x(00)00271-7. Bioorg Med Chem Lett. 2000. PMID: 10888335

9

Assessment of solution-phase positional scanning libraries based on distamycin A for the discovery of new DNA binding agents.

Boger DL, Dechantsreiter MA, Ishii T, Fink BE, Hedrick MP. Boger DL, et al. Among authors: hedrick mp. Bioorg Med Chem. 2000 Aug;8(8):2049-57. doi: 10.1016/s0968-0896(00)00137-1. Bioorg Med Chem. 2000. PMID: 11003149

10

alpha-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and alpha-substitution.

Boger DL, Miyauchi H, Hedrick MP. Boger DL, et al. Among authors: hedrick mp. Bioorg Med Chem Lett. 2001 Jun 18;11(12):1517-20. doi: 10.1016/s0960-894x(01)00211-6. Bioorg Med Chem Lett. 2001. PMID: 11412972

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