Moore LB - Search Results

1

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor.

Moore LB, Goodwin B, Jones SA, Wisely GB, Serabjit-Singh CJ, Willson TM, Collins JL, Kliewer SA. Moore LB, et al. Proc Natl Acad Sci U S A. 2000 Jun 20;97(13):7500-2. doi: 10.1073/pnas.130155097. Proc Natl Acad Sci U S A. 2000. PMID: 10852961 Free PMC article.

2

A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation.

Oberfield JL, Collins JL, Holmes CP, Goreham DM, Cooper JP, Cobb JE, Lenhard JM, Hull-Ryde EA, Mohr CP, Blanchard SG, Parks DJ, Moore LB, Lehmann JM, Plunket K, Miller AB, Milburn MV, Kliewer SA, Willson TM. Oberfield JL, et al. Among authors: moore lb. Proc Natl Acad Sci U S A. 1999 May 25;96(11):6102-6. doi: 10.1073/pnas.96.11.6102. Proc Natl Acad Sci U S A. 1999. PMID: 10339548 Free PMC article.

3

The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution.

Jones SA, Moore LB, Shenk JL, Wisely GB, Hamilton GA, McKee DD, Tomkinson NC, LeCluyse EL, Lambert MH, Willson TM, Kliewer SA, Moore JT. Jones SA, et al. Among authors: moore lb, moore jt. Mol Endocrinol. 2000 Jan;14(1):27-39. doi: 10.1210/mend.14.1.0409. Mol Endocrinol. 2000. PMID: 10628745

4

Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands.

Moore LB, Parks DJ, Jones SA, Bledsoe RK, Consler TG, Stimmel JB, Goodwin B, Liddle C, Blanchard SG, Willson TM, Collins JL, Kliewer SA. Moore LB, et al. J Biol Chem. 2000 May 19;275(20):15122-7. doi: 10.1074/jbc.M001215200. J Biol Chem. 2000. PMID: 10748001 Free article.

5

Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor.

Goodwin B, Moore LB, Stoltz CM, McKee DD, Kliewer SA. Goodwin B, et al. Among authors: moore lb. Mol Pharmacol. 2001 Sep;60(3):427-31. Mol Pharmacol. 2001. PMID: 11502872

6

Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors.

Xu HE, Lambert MH, Montana VG, Plunket KD, Moore LB, Collins JL, Oplinger JA, Kliewer SA, Gampe RT Jr, McKee DD, Moore JT, Willson TM. Xu HE, et al. Among authors: moore lb, moore jt. Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13919-24. doi: 10.1073/pnas.241410198. Epub 2001 Nov 6. Proc Natl Acad Sci U S A. 2001. PMID: 11698662 Free PMC article.

7

Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genes.

Maglich JM, Parks DJ, Moore LB, Collins JL, Goodwin B, Billin AN, Stoltz CA, Kliewer SA, Lambert MH, Willson TM, Moore JT. Maglich JM, et al. Among authors: moore lb, moore jt. J Biol Chem. 2003 May 9;278(19):17277-83. doi: 10.1074/jbc.M300138200. Epub 2003 Feb 27. J Biol Chem. 2003. PMID: 12611900 Free article.

8

Structural disorder in the complex of human pregnane X receptor and the macrolide antibiotic rifampicin.

Chrencik JE, Orans J, Moore LB, Xue Y, Peng L, Collins JL, Wisely GB, Lambert MH, Kliewer SA, Redinbo MR. Chrencik JE, et al. Among authors: moore lb. Mol Endocrinol. 2005 May;19(5):1125-34. doi: 10.1210/me.2004-0346. Epub 2005 Feb 10. Mol Endocrinol. 2005. PMID: 15705662

9

Pregnane X receptor (PXR), constitutive androstane receptor (CAR), and benzoate X receptor (BXR) define three pharmacologically distinct classes of nuclear receptors.

Moore LB, Maglich JM, McKee DD, Wisely B, Willson TM, Kliewer SA, Lambert MH, Moore JT. Moore LB, et al. Among authors: moore jt. Mol Endocrinol. 2002 May;16(5):977-86. doi: 10.1210/mend.16.5.0828. Mol Endocrinol. 2002. PMID: 11981033

10

Use of in vitro pregnane X receptor assays to assess CYP3A4 induction potential of drug candidates.

Jones SA, Moore LB, Wisely GB, Kliewer SA. Jones SA, et al. Among authors: moore lb. Methods Enzymol. 2002;357:161-70. doi: 10.1016/s0076-6879(02)57675-8. Methods Enzymol. 2002. PMID: 12424907 No abstract available.

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