Takayama H - Search Results

1

Syntheses and biological evaluation of novel 2alpha-substituted 1alpha,25-dihydroxyvitamin D3 analogues.

Suhara Y, Nihei KI, Tanigawa H, Fujishima T, Konno K, Nakagawa K, Okano T, Takayama H. Suhara Y, et al. Among authors: takayama h. Bioorg Med Chem Lett. 2000 May 15;10(10):1129-32. doi: 10.1016/s0960-894x(00)00189-x. Bioorg Med Chem Lett. 2000. PMID: 10843234

2

Synthesis and testing of 2alpha-modified 1alpha,25-dihydroxyvitamin D(3) analogues with a double side chain: marked cell differentiation activity.

Suhara Y, Kittaka A, Kishimoto S, Calverley MJ, Fujishima T, Saito N, Sugiura T, Waku K, Takayama H. Suhara Y, et al. Among authors: takayama h. Bioorg Med Chem Lett. 2002 Nov 18;12(22):3255-8. doi: 10.1016/s0960-894x(02)00722-9. Bioorg Med Chem Lett. 2002. PMID: 12392726

3

Design and efficient synthesis of new stable 1alpha,25-dihydroxy-19-norvitamin D3 analogues containing amide bond.

Suhara Y, Kittaka A, Ono K, Kurihara M, Fujishima T, Yoshida A, Takayama H. Suhara Y, et al. Among authors: takayama h. Bioorg Med Chem Lett. 2002 Dec 16;12(24):3533-6. doi: 10.1016/s0960-894x(02)00800-4. Bioorg Med Chem Lett. 2002. PMID: 12443770

4

Design, synthesis, and biological studies of the A-ring-modified 1,25-dihydroxyvitamin D3 analogs.

Takayama H, Kittaka A, Fujishima T, Suhara Y. Takayama H, et al. Recent Results Cancer Res. 2003;164:289-317. doi: 10.1007/978-3-642-55580-0_21. Recent Results Cancer Res. 2003. PMID: 12899530 Review.

5

Design and synthesis of potent vitamin D receptor antagonists with A-ring modifications: remarkable effects of 2alpha-methyl introduction on antagonistic activity.

Fujishima T, Kojima Y, Azumaya I, Kittaka A, Takayama H. Fujishima T, et al. Among authors: takayama h. Bioorg Med Chem. 2003 Aug 15;11(17):3621-31. doi: 10.1016/s0968-0896(03)00371-7. Bioorg Med Chem. 2003. PMID: 12901907

6

Efficient synthesis of 2-modified 1alpha,25-dihydroxy-19-norvitamin D3 with Julia olefination: high potency in induction of differentiation on HL-60 cells.

Ono K, Yoshida A, Saito N, Fujishima T, Honzawa S, Suhara Y, Kishimoto S, Sugiura T, Waku K, Takayama H, Kittaka A. Ono K, et al. Among authors: takayama h. J Org Chem. 2003 Sep 19;68(19):7407-15. doi: 10.1021/jo034787y. J Org Chem. 2003. PMID: 12968893

7

Concise synthesis and biological activities of 2alpha-alkyl- and 2alpha-(omega-hydroxyalkyl)-20-epi-1alpha,25-dihydroxyvitamin D3.

Honzawa S, Suhara Y, Nihei K, Saito N, Kishimoto S, Fujishima T, Kurihara M, Sugiura T, Waku K, Takayama H, Kittaka A. Honzawa S, et al. Among authors: takayama h. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3503-6. doi: 10.1016/s0960-894x(03)00739-x. Bioorg Med Chem Lett. 2003. PMID: 14505658

8

Design and efficient synthesis of 2 alpha-(omega-hydroxyalkoxy)-1 alpha,25-dihydroxyvitamin D3 Analogues, including 2-epi-ED-71 and their 20-epimers with HL-60 cell differentiation activity.

Saito N, Suhara Y, Kurihara M, Fujishima T, Honzawa S, Takayanagi H, Kozono T, Matsumoto M, Ohmori M, Miyata N, Takayama H, Kittaka A. Saito N, et al. Among authors: takayama h. J Org Chem. 2004 Oct 29;69(22):7463-71. doi: 10.1021/jo0491051. J Org Chem. 2004. PMID: 15497970

9

Probing a water channel near the A-ring of receptor-bound 1 alpha,25-dihydroxyvitamin D3 with selected 2 alpha-substituted analogues.

Hourai S, Fujishima T, Kittaka A, Suhara Y, Takayama H, Rochel N, Moras D. Hourai S, et al. Among authors: takayama h. J Med Chem. 2006 Aug 24;49(17):5199-205. doi: 10.1021/jm0604070. J Med Chem. 2006. PMID: 16913708

10

Biological activities of 2alpha-substituted analogues of 1alpha,25-dihydroxyvitamin D3 in transcriptional regulation and human promyelocytic leukemia (HL-60) cell proliferation and differentiation.

Takahashi E, Nakagawa K, Suhara Y, Kittaka A, Nihei K, Konno K, Takayama H, Ozono K, Okano T. Takahashi E, et al. Among authors: takayama h. Biol Pharm Bull. 2006 Nov;29(11):2246-50. doi: 10.1248/bpb.29.2246. Biol Pharm Bull. 2006. PMID: 17077522 Free article.

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