Tsai LH - Search Results

1

Neurotoxicity induces cleavage of p35 to p25 by calpain.

Lee MS, Kwon YT, Li M, Peng J, Friedlander RM, Tsai LH. Lee MS, et al. Among authors: tsai lh. Nature. 2000 May 18;405(6784):360-4. doi: 10.1038/35012636. Nature. 2000. PMID: 10830966

2

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5.

Tsai LH, Delalle I, Caviness VS Jr, Chae T, Harlow E. Tsai LH, et al. Nature. 1994 Sep 29;371(6496):419-23. doi: 10.1038/371419a0. Nature. 1994. PMID: 8090221

3

The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation.

Nikolic M, Dudek H, Kwon YT, Ramos YF, Tsai LH. Nikolic M, et al. Among authors: tsai lh. Genes Dev. 1996 Apr 1;10(7):816-25. doi: 10.1101/gad.10.7.816. Genes Dev. 1996. PMID: 8846918 Free article.

4

A structural basis for substrate specificities of protein Ser/Thr kinases: primary sequence preference of casein kinases I and II, NIMA, phosphorylase kinase, calmodulin-dependent kinase II, CDK5, and Erk1.

Songyang Z, Lu KP, Kwon YT, Tsai LH, Filhol O, Cochet C, Brickey DA, Soderling TR, Bartleson C, Graves DJ, DeMaggio AJ, Hoekstra MF, Blenis J, Hunter T, Cantley LC. Songyang Z, et al. Among authors: tsai lh. Mol Cell Biol. 1996 Nov;16(11):6486-93. doi: 10.1128/MCB.16.11.6486. Mol Cell Biol. 1996. PMID: 8887677 Free PMC article.

5

Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality.

Chae T, Kwon YT, Bronson R, Dikkes P, Li E, Tsai LH. Chae T, et al. Among authors: tsai lh. Neuron. 1997 Jan;18(1):29-42. doi: 10.1016/s0896-6273(01)80044-1. Neuron. 1997. PMID: 9010203 Free article.

6

A novel disruption of cortical development in p35(-/-) mice distinct from reeler.

Kwon YT, Tsai LH. Kwon YT, et al. Among authors: tsai lh. J Comp Neurol. 1998 Jun 15;395(4):510-22. doi: 10.1002/(sici)1096-9861(19980615)395:4<510::aid-cne7>3.0.co;2-4. J Comp Neurol. 1998. PMID: 9619503

7

p35, the neuronal-specific activator of cyclin-dependent kinase 5 (Cdk5) is degraded by the ubiquitin-proteasome pathway.

Patrick GN, Zhou P, Kwon YT, Howley PM, Tsai LH. Patrick GN, et al. Among authors: tsai lh. J Biol Chem. 1998 Sep 11;273(37):24057-64. doi: 10.1074/jbc.273.37.24057. J Biol Chem. 1998. PMID: 9727024 Free article.

8

The p35/Cdk5 kinase is a neuron-specific Rac effector that inhibits Pak1 activity.

Nikolic M, Chou MM, Lu W, Mayer BJ, Tsai LH. Nikolic M, et al. Among authors: tsai lh. Nature. 1998 Sep 10;395(6698):194-8. doi: 10.1038/26034. Nature. 1998. PMID: 9744280

9

Callosal axon guidance defects in p35(-/-) mice.

Kwon YT, Tsai LH, Crandall JE. Kwon YT, et al. Among authors: tsai lh. J Comp Neurol. 1999 Dec 13;415(2):218-29. doi: 10.1002/(sici)1096-9861(19991213)415:2<218::aid-cne6>3.0.co;2-f. J Comp Neurol. 1999. PMID: 10545161

10

Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration.

Patrick GN, Zukerberg L, Nikolic M, de la Monte S, Dikkes P, Tsai LH. Patrick GN, et al. Among authors: tsai lh. Nature. 1999 Dec 9;402(6762):615-22. doi: 10.1038/45159. Nature. 1999. PMID: 10604467

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